Coxiella com1 antibody and antigen (recombinant protein)

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Diagnostic anti-Coxiella com1 antibodies pairs and antigen for animal health (animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat infectious disease Q fever) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P042-Tg001-Ag01	Recombinant Coxiella com1 protein	$3090.00
GMP-VT-P042-Tg001-Ab01	Anti-Coxiella com1 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P042-Tg001-Ab02	Anti-Coxiella com1 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P042-Tg001-Ab03	Anti-Coxiella com1 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P042-Tg001-Ab04	Anti-Coxiella com1 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P042-Tg001-Ag01
Product Name	Recombinant Coxiella com1 protein
Pathogen	Coxiella
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Coxiella com1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Coxiella level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat infectious disease with Q fever.
Tag	His
Product description	Recombinant Coxiella com1 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P042-Tg001-Ab01,GMP-VT-P042-Tg001-Ab02
Pathogen	Coxiella
Product Name	Anti-Coxiella com1 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Coxiella com1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Coxiella antibodies in Coxiella level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat infectious disease with Q fever.
Product description	Anti-Coxiella com1 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Coxiella antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P042-Tg001-Ab03,GMP-VT-P042-Tg001-Ab04
Pathogen	Coxiella
Product Name	Anti-Coxiella com1 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Coxiella com1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Coxiella antibodies in Coxiella level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat infectious disease with Q fever.
Product description	Anti-Coxiella com1 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Swine Chlamydiaceae, also known as Porcine Chlamydiaceae or Pig Chlamydiaceae, are a group of obligate intracellular pathogens belonging to the family Chlamydiaceae. This family is part of the phylum Chlamydiae and order Chlamydiales, which encompasses a diverse range of bacteria characterized by their unique biphasic developmental cycle.

The key genetic element in Swine Chlamydiaceae is the outer membrane protein A (ompA) gene. This gene encodes for the outer membrane protein A, which plays a crucial role in host cell attachment and entry. The ompA protein is a major target for immune responses and can vary between different species and strains of the bacterium, contributing to its antigenic diversity.

Swine Chlamydiaceae can infect various hosts, including pigs (Sus scrofa), humans, and other animals. In pigs, the infection can cause porcine chlamydiosis, which is characterized by respiratory disease, reproductive disorders, and conjunctivitis. Respiratory manifestations include coughing, sneezing, and nasal discharge. Reproductive disorders may lead to infertility, abortion, or stillbirths in sows. Conjunctivitis, or inflammation of the eye, can also occur in infected pigs.

In humans, zoonotic infections caused by Swine Chlamydiaceae can manifest as psittacosis and pneumonia. Psittacosis, also known as parrot fever, is typically acquired through exposure to infected birds, such as parrots, pigeons, and ducks. Symptoms of psittacosis in humans include fever, headache, muscle aches, and respiratory symptoms like cough and shortness of breath. Pneumonia caused by Swine Chlamydiaceae is rare but can occur, leading to respiratory complications.

Diagnosis of Swine Chlamydiaceae infection involves a combination of clinical presentation, laboratory tests, and molecular techniques. Serological tests are commonly used to detect the presence of antibodies against the bacterium in the blood. These tests, such as enzyme-linked immunosorbent assays (ELISAs), can indicate past or current infections. However, serology alone cannot provide definitive diagnosis due to cross-reactivity with other Chlamydia species.

To confirm the presence of Swine Chlamydiaceae, antigen detection assays can be utilized. These tests detect pathogen-specific proteins, such as the major outer membrane protein (MOMP), using techniques like immunofluorescence or enzyme immunoassays. Antigen detection can provide rapid results, aiding in early diagnosis and treatment.

Nucleic acid amplification tests, such as polymerase chain reaction (PCR), are highly sensitive and specific methods for detecting Swine Chlamydiaceae. These tests target specific genes, including ompA, MOMP, and the heat shock protein 60 (HSP60) gene. PCR can detect the presence of the bacterium directly from clinical samples, such as swabs or tissues, allowing for early and accurate diagnosis.

Treatment of Swine Chlamydiaceae infections typically involves the use of antibiotics, such as tetracyclines or macrolides. However, it is important to note that antibiotic resistance can occur, emphasizing the need for appropriate antibiotic selection and monitoring. Prevention strategies include strict biosecurity measures, proper hygiene practices, and vaccination where available.

In conclusion, Swine/Porcine/Pig Chlamydiaceae are intracellular pathogens that can cause respiratory disease, reproductive disorders, and conjunctivitis in pigs. They can also infect humans, leading to psittacosis and pneumonia. Diagnosis involves serological tests, antigen detection assays, and nucleic acid amplification tests like PCR. Early and accurate diagnosis is crucial for effective treatment and prevention of further spread.

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