Streptococcus equi SeM antibody and antigen (recombinant protein)
Diagnostic anti-Streptococcus equi SeM antibodies pairs and antigen for animal health (animal Equine/Horse infectious disease Strangles) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-VT-P146-Tg001-Ag01 | Recombinant Streptococcus equi SeM protein | $3090.00 |
GMP-VT-P146-Tg001-Ab01 | Anti-Streptococcus equi SeM mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P146-Tg001-Ab02 | Anti-Streptococcus equi SeM mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P146-Tg001-Ab03 | Anti-Streptococcus equi SeM human monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P146-Tg001-Ab04 | Anti-Streptococcus equi SeM human monoclonal antibody (mAb) | $3090.00 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. | GMP-VT-P146-Tg001-Ag01 |
Product Name | Recombinant Streptococcus equi SeM protein |
Pathogen | Streptococcus equi |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-Streptococcus equi SeM antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Streptococcus equi level test of animal Equine/Horse infectious disease with Strangles. |
Tag | His | Product description | Recombinant Streptococcus equi SeM proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P146-Tg001-Ab01,GMP-VT-P146-Tg001-Ab02 |
Pathogen | Streptococcus equi |
Product Name | Anti-Streptococcus equi SeM mouse monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant Streptococcus equi SeM antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Streptococcus equi antibodies in Streptococcus equi level test of animal Equine/Horse infectious disease with Strangles. |
Product description | Anti-Streptococcus equi SeM mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Streptococcus equi antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P146-Tg001-Ab03,GMP-VT-P146-Tg001-Ab04 |
Pathogen | Streptococcus equi |
Product Name | Anti-Streptococcus equi SeM human monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Human lgG1 |
Bioactivity validation | Recombinant Streptococcus equi SeM antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Streptococcus equi antibodies in Streptococcus equi level test of animal Equine/Horse infectious disease with Strangles. |
Product description | Anti-Streptococcus equi SeM mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Pathogen Information
Streptococcus equi: Understanding the Equine Pathogen
Streptococcus equi, commonly known as S. equi, stands as a significant pathogen in the equine world, causing the highly contagious and often debilitating disease known as "Strangles." This gram-positive bacterium falls under the phylum Firmicutes and the genus Streptococcus, sharing its lineage with various other streptococcal species, some of which are benign inhabitants of the mammalian oral cavity and respiratory tract.
1. Pathogen Characteristics:
S. equi presents itself as a spherical, non-motile, and non-spore-forming bacterium. Its distinct classification as a gram-positive organism implies that it possesses a thick peptidoglycan layer in its cell wall, which retains the crystal violet stain during the Gram staining process. This characteristic gives the bacterial cell its purple color under the microscope. The bacterium reproduces through binary fission, wherein a single cell divides into two identical daughter cells.
2. Virulence Factors and Pathogenicity:
At the heart of S. equi's pathogenicity lies the M-protein, a crucial virulence factor encoded by the 'sceE' gene. The M-protein facilitates adhesion to host epithelial cells, allowing the bacterium to establish infection in the upper respiratory tract. Moreover, it aids in immune system evasion by inhibiting phagocytosis, allowing the bacterium to persist within the host and cause disease.
3. Strangles: Clinical Manifestations and Host Range:
Strangles, the disease caused by S. equi, primarily affects horses, ponies, and other equids. The infection typically starts in the upper respiratory tract, leading to symptoms such as fever, purulent nasal discharge, swelling, and abscess formation in the lymph nodes of the head and neck. Affected animals often experience difficulty swallowing, leading to the disease's peculiar name due to the strangled breathing sounds that affected horses may produce. In severe cases, the infection can progress to cause respiratory distress, posing a significant threat to the animal's health.
4. Diagnostic Methods:
Accurate and timely diagnosis of Streptococcus equi infection is paramount in controlling its spread within equine populations. Several diagnostic methods are employed:
a. Cultural Isolation: Clinical samples, including nasal swabs and abscess contents, are cultured on selective media. The characteristic colonies of S. equi can be identified through their morphology and biochemical tests.
b. Polymerase Chain Reaction (PCR): PCR assays targeting specific genetic markers, such as the 'sceE' gene, enable the amplification and detection of S. equi DNA. This method offers high sensitivity and specificity, crucial for early detection.
c. Serological Tests: Enzyme-Linked Immunosorbent Assays (ELISA) detect antibodies against S. equi in the blood serum of infected animals. Seropositivity indicates exposure or ongoing infection.
d. Genomic Sequencing: Advanced molecular techniques involve whole-genome sequencing of S. equi isolates. This approach provides insights into the bacterium's genetic diversity, aiding researchers in tracking outbreaks and understanding the evolution of virulent strains.
5. Conclusion:
Streptococcus equi, with its intricate pathogenic mechanisms and diverse clinical manifestations, underscores the importance of vigilant monitoring and rapid diagnostics within equine populations. Ongoing research aimed at deciphering the bacterium's genetic intricacies and host interactions is vital in devising effective prevention and treatment strategies. As we delve deeper into the molecular nuances of S. equi, equine healthcare professionals and researchers are better equipped to safeguard the well-being of our beloved equine companions, ensuring their resilience against this formidable pathogen.
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