Mycoplasma synoviae antibody and antigen (recombinant protein)

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Diagnostic anti-Mycoplasma synoviae antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Infectious Synovitis, Avian Mycoplasmosis, Infectious Sinusitis and Mycoplasma Arthritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P178-Ag01	Recombinant Mycoplasma synoviae protein	$3090.00
GMP-VT-P178-Ab01	Anti-Mycoplasma synoviae mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P178-Ab02	Anti-Mycoplasma synoviae mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P178-Ag01
Product Name	Recombinant Mycoplasma synoviae protein
Pathogen	Mycoplasma synoviae
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Mycoplasma synoviae antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Mycoplasma synoviae level test of animal Avian/Bird/Poultry infectious disease with Infectious Synovitis, Avian Mycoplasmosis, Infectious Sinusitis and Mycoplasma Arthritis.
Tag	His
Product description	Recombinant Mycoplasma synoviae proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P178-Ab01,GMP-VT-P178-Ab02
Pathogen	Mycoplasma synoviae
Product Name	Anti-Mycoplasma synoviae mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Mycoplasma synoviae antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma synoviae antibodies in Mycoplasma synoviae level test of animal Avian/Bird/Poultry infectious disease with Infectious Synovitis, Avian Mycoplasmosis, Infectious Sinusitis and Mycoplasma Arthritis.
Product description	Anti-Mycoplasma synoviae mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma synoviae antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Mycoplasma synoviae is a pathogenic bacterium that primarily affects avian species. This organism is a member of the Mollicutes class, a group of prokaryotic bacteria that lack a cell wall. Mycoplasmas are considered to be among the smallest free-living organisms and are known for their ability to infect a wide range of hosts, including humans, animals, and plants.

The Mycoplasmataceae family is a large and diverse group of bacteria that includes many important human and animal pathogens. Some members of this family can cause respiratory illness, genitourinary tract infections, and other diseases. Mycoplasma synoviae, in particular, is known to cause respiratory disease, synovitis (inflammation of the joints), and reproductive disorders in birds.

The Mycoplasma synoviae genome is relatively small, consisting of approximately 800 kilobase pairs. Despite its small size, this genome contains a number of genes and proteins that are critical for the bacterium's survival and pathogenesis. Key genes in Mycoplasma synoviae include vlhA, mgc2, and pvpA.

The vlhA gene encodes for variable surface antigens, which enable the bacterium to evade the host immune system and contribute to persistent infection. The mgc2 gene encodes for Mgc2, a cytadherence protein that mediates binding to host cells and contributes to the formation of specialized attachment organelles known as cytadheresomes. The pvpA gene encodes for PvpA, a protease that has been implicated in the degradation of host extracellular matrix components and the modulation of host inflammatory responses.

Mycoplasma synoviae primarily infects chickens and turkeys, though other birds may also be affected. The bacterium is transmitted horizontally through respiratory secretions and vertically from infected hens to their offspring. Pathogenicity of Mycoplasma synoviae is thought to be mediated by the expression of various virulence factors, including the aforementioned vlhA, mgc2, and pvpA genes.

Signs of Mycoplasma synoviae infection in chickens can include respiratory distress, nasal discharge, and conjunctivitis. Affected birds may also show signs of swelling or lameness due to synovitis. In severe cases, egg production may decline or cease altogether, leading to significant economic losses for producers.

Diagnostic methods for Mycoplasma synoviae include bacterial culture, serological assays, polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA). PCR and ELISA are the most common methods used for diagnosis, as they are highly sensitive and specific. These methods typically target the vlhA gene or the Mgc2 protein for detection. Culture-based methods, while less sensitive, remain the gold standard for definitive diagnosis of Mycoplasma synoviae infection.

In conclusion, Mycoplasma synoviae is a small but significant bacterial pathogen that primarily affects avian species. The bacterium's ability to cause respiratory disease, synovitis, and reproductive disorders can lead to significant economic losses in the poultry industry. Nevertheless, advances in diagnostic methods and disease management strategies continue to improve our understanding of Mycoplasma synoviae and our ability to prevent and treat infections caused by this pathogen.

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