Bordetella avium ompA antibody and antigen (recombinant protein)

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Diagnostic anti-Bordetella avium ompA antibodies pairs and antigen for animal health (animal Turkey infectious disease bordetellosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P201-Tg001-Ag01	Recombinant Bordetella avium ompA protein	$3090.00
GMP-VT-P201-Tg001-Ab01	Anti-Bordetella avium ompA mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P201-Tg001-Ab02	Anti-Bordetella avium ompA mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P201-Tg001-Ab03	Anti-Bordetella avium ompA human monoclonal antibody (mAb)	$3090.00
GMP-VT-P201-Tg001-Ab04	Anti-Bordetella avium ompA human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P201-Tg001-Ag01
Product Name	Recombinant Bordetella avium ompA protein
Pathogen	Bordetella avium
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bordetella avium ompA antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Bordetella avium level test of animal Turkey infectious disease with bordetellosis.
Tag	His
Product description	Recombinant Bordetella avium ompA proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P201-Tg001-Ab01,GMP-VT-P201-Tg001-Ab02
Pathogen	Bordetella avium
Product Name	Anti-Bordetella avium ompA mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bordetella avium ompA antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bordetella avium antibodies in Bordetella avium level test of animal Turkey infectious disease with bordetellosis.
Product description	Anti-Bordetella avium ompA mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bordetella avium antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P201-Tg001-Ab03,GMP-VT-P201-Tg001-Ab04
Pathogen	Bordetella avium
Product Name	Anti-Bordetella avium ompA human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Bordetella avium ompA antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bordetella avium antibodies in Bordetella avium level test of animal Turkey infectious disease with bordetellosis.
Product description	Anti-Bordetella avium ompA mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Bordetella avium is a gram-negative bacterium that belongs to the genus Bordetella. This bacterium is known to cause respiratory disease in birds, including poultry and wild birds. Avian bordetellosis is a highly contagious bacterial disease caused by Bordetella avium, which is characterized by respiratory symptoms such as coughing, sneezing, and nasal discharge.

Bordetella avium is a rod-shaped bacterium that is typically 1-3 micrometers in length and 0.2-0.5 micrometers in diameter. It has a relatively simple cell structure, consisting of a cell membrane, cytoplasm, and nucleoid region. The cell wall of Bordetella avium is made up of peptidoglycan, lipopolysaccharides (LPS), and several other proteins.

The virulence of Bordetella avium is regulated by the bvgA gene, which encodes for a transcriptional activator that controls the expression of virulence factors. This gene is part of the BvgAS two-component system, which enables the bacterium to sense changes in its environment and respond accordingly. When the bacterium encounters specific environmental signals, such as temperature and nutrient availability, the BvgAS system activates the expression of virulence genes, including the filamentous hemagglutinin (FHA) protein.

FHA is a major virulence factor of Bordetella avium, which plays a crucial role in attachment to host cells. This protein is composed of several subunits, including FhaB, FhaC, and FhaD. FhaB is the largest subunit, which contains a receptor-binding domain that allows the bacterium to attach to specific receptors on the surface of host cells. FhaC and FhaD are minor subunits that form a pore-like structure in the bacterial outer membrane, which enables FHA to be transported to the cell surface.

Bordetella avium primarily infects birds, including wild and domesticated poultry. The disease can spread rapidly through bird populations, causing significant economic losses in the poultry industry. Avian bordetellosis is characterized by respiratory symptoms such as coughing, sneezing, and nasal discharge. Affected birds may also experience decreased egg production and increased mortality rates.

Diagnostic methods for Bordetella avium include bacterial culture, polymerase chain reaction (PCR), and serology. Bacterial culture involves the isolation and identification of the bacterium from infected tissue samples. PCR targets the bvgA gene, which is specific to Bordetella avium. Serology detects antibodies against the FHA protein, which can be used to confirm exposure to the bacterium. Nucleic acid-based diagnostic methods, such as PCR, are particularly useful for detecting low levels of the bacterium in asymptomatic carriers.

In conclusion, Bordetella avium is a gram-negative bacterium that causes respiratory disease in birds. This bacterium is highly contagious and can cause significant economic losses in the poultry industry. Understanding the structure and virulence factors of Bordetella avium is essential for developing effective control strategies. Diagnostic methods such as bacterial culture, PCR, and serology can aid in the detection and identification of this pathogen.

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