Beak and feather disease virus Capsid protein antibody and antigen (recombinant protein)

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Diagnostic anti-Beak and feather disease virus Capsid protein antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Psittacine beak and feather disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P226-Tg001-Ag01	Recombinant Beak and feather disease virus Capsid protein protein	$3090.00
GMP-VT-P226-Tg001-Ab01	Anti-Beak and feather disease virus Capsid protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P226-Tg001-Ab02	Anti-Beak and feather disease virus Capsid protein mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P226-Tg001-Ab03	Anti-Beak and feather disease virus Capsid protein human monoclonal antibody (mAb)	$3090.00
GMP-VT-P226-Tg001-Ab04	Anti-Beak and feather disease virus Capsid protein human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P226-Tg001-Ag01
Product Name	Recombinant Beak and feather disease virus Capsid protein protein
Pathogen	Beak and feather disease virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Beak and feather disease virus Capsid protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Beak and feather disease virus level test of animal Avian/Bird/Poultry infectious disease with Psittacine beak and feather disease.
Tag	His
Product description	Recombinant Beak and feather disease virus Capsid protein proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P226-Tg001-Ab01,GMP-VT-P226-Tg001-Ab02
Pathogen	Beak and feather disease virus
Product Name	Anti-Beak and feather disease virus Capsid protein mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Beak and feather disease virus Capsid protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Beak and feather disease virus antibodies in Beak and feather disease virus level test of animal Avian/Bird/Poultry infectious disease with Psittacine beak and feather disease.
Product description	Anti-Beak and feather disease virus Capsid protein mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Beak and feather disease virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P226-Tg001-Ab03,GMP-VT-P226-Tg001-Ab04
Pathogen	Beak and feather disease virus
Product Name	Anti-Beak and feather disease virus Capsid protein human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Beak and feather disease virus Capsid protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Beak and feather disease virus antibodies in Beak and feather disease virus level test of animal Avian/Bird/Poultry infectious disease with Psittacine beak and feather disease.
Product description	Anti-Beak and feather disease virus Capsid protein mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Beak and feather disease virus (BFDV) is a virus that primarily infects birds. It belongs to the family Circoviridae, a group of small, non-enveloped viruses that possess a circular single-stranded DNA genome. BFDV is relatively small, consisting of a genome of approximately 2kb in length that encodes two major proteins, including the capsid protein VP1.

BFDV has been reported worldwide, affecting a wide range of bird species. However, psittacines, such as parrots, macaws, and cockatoos, are considered to be the most susceptible hosts. Feral and wild populations have also been found to be infected with BFDV, indicating that the virus can be transmitted between domestic and wild populations.

BFDV infection causes a disease known as beak and feather disease (BFD), which is characterized by developmental abnormalities of the beak and feathers as well as immune system dysfunction. The severity of the symptoms can vary widely depending on the age and species of the host bird as well as the virulence of the strain of BFDV that is involved. Clinical signs of BFD can include progressive development of beak abnormalities, feather loss, feather malformations, and sometimes weight loss or lethargy.

BFDV transmission occurs mainly via oral-fecal routes, with infected birds shedding the virus in their saliva, feces, and respiratory secretions. BFDV can also be transmitted through contaminated surfaces, such as food and water dishes, and can persist for long periods in the environment. Hence, this implies that birds housed in close proximity are at high risk of contracting BFDV.

Diagnostic methods for BFDV include PCR-based detection of viral DNA, serological assays, in situ hybridization, electron microscopy, and histopathology. PCR-based assays have been developed to target specific regions of the BFDV genome, including the capsid protein VP1. Serological assays can detect antibodies to BFDV in bird sera or plasma and are useful for monitoring the spread of BFDV within flocks.

In situ hybridization and histopathology examinations have been used to confirm the presence of BFDV within infected birds. However, a combination of these methods is required for accurate diagnosis, as some infected birds may not present with severe clinical signs but may still harbor the virus.

The control and prevention of BFDV infection mainly involve strict biosecurity measures, including regular disinfection of cages and equipment, the quarantine of new birds entering a flock, and the culling of infected individuals. These measures should be combined with regular testing and monitoring of flock health to identify any potential outbreaks early.

In conclusion, BFDV is a small, single-stranded circular DNA virus that primarily infects birds, causing a disease known as beak and feather disease. The virus is transmitted through oral-fecal routes, and infected birds shed the virus in their saliva, feces, and respiratory secretions. The severity of the disease can vary widely depending on the age and species of the host bird as well as the virulence of the strain involved. Accurate diagnosis of BFDV infection requires a combination of techniques, including PCR-based assays, serological assays, in situ hybridization, electron microscopy, and histopathology. Strict biosecurity measures, regular testing, and monitoring of flock health are essential for controlling and preventing the spread of BFDV within bird populations.

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