Pre-made Alemtuzumab benchmark antibody ( Whole mAb, anti-CD52 therapeutic antibody, Anti-HE5/CDW52/EDDM5 Antibody) for drug discovery and mechanism of action (MOA) research

Cat No.: GMP-Bios-ab-015

Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. In CLL, it has been used as both a first line and second line treatment. In MS it is generally only recommended if other treatments have not worked. It is given by injection into a vein.

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GMP-Bios-ab-015-1mg 1mg 3090 Inquiry Inquiry

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Description

Products Name (INN Index) Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody
INN Name Alemtuzumab
TargetCD52
FormatWhole mAb
DerivationHumanized
Species ReactivityHuman
CH1 IsotypeIgG1
VD LCKappa
Highest_Clin_Trial (Jan '20)Approved
Est. StatusActive
100% SI Structure1bey:HL/1ce1:HL
99% SI StructureNone
95-98% SI StructureNone
Year Proposed2000
Year Recommended2001
CompaniesBayer HealthCare Pharmaceuticals Inc.;Dana-Farber Cancer Institute;German CLL Study Group;Ohio State University Comprehensive Cancer Center;Sanofi;Sanofi Oncology;University of Cologne;University of Cambridge
Conditions ApprovedChronic lymphocytic leukaemia;Multiple sclerosis
Conditions ActiveLymphoma;T-cell prolymphocytic leukaemia
Conditions DiscontinuedRheumatoid arthritis;Diffuse large B cell lymphoma;Graft-versus-host disease;Sezary syndrome;T-cell lymphoma
Development Techna