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Bavituximab Biosimilar Monoclonal Antibody (Phosphatidylserine) for Research
Pre-Made Bavituximab biosimilar, Whole Mab: Anti-Phosphatidylserine therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and when cells are infected with hepatitis C.[3] The process of cell death is highly controlled and so there usually no immune response to phosphatidylserine but when bavituximab binds to it, the conjugate appears to stimulate an immune response in humans.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-051-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Bavituximab biosimilar, Whole Mab: Anti-Phosphatidylserine therapeutic antibody |
| INN Name | Bavituximab |
| Target | Phosphatidylserine |
| Format | Whole mAb |
| Derivation | Chimeric (Mouse/Human) |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-III |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2006 |
| Year Recommended | 2007 |
| Companies | Avid Bioservices;IMV;Massachusetts General Hospital;Merck Sharp & Dohme;Peregrine Pharmaceuticals;University of Arizona;University of Texas Southwestern Medical Center;University of Texas M. D. Anderson Cancer Center |
| Conditions Approved | na |
| Conditions Active | Non-small cell lung cancer;Glioblastoma;Liver cancer;Solid tumours |
| Conditions Discontinued | Breast cancer;Malignant melanoma;Pancreatic cancer;Brain cancer;Hepatitis C;HIV infections;Rectal cancer;Viral haemorrhagic fevers;Influenza virus infections;Prostate cancer |
| Development Tech | na |
About target - Phosphatidylserine
1. Protein Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
2. Gene PSD1
3. Organism Homo sapiens (Human)
Function
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:8227017, PubMed:8407984, PubMed:17976194, PubMed:23124206, PubMed:25829489).
Phosphatidylethanolamine formed in the mitochondria is exported to other membranes to fullfill their requirements for PtdEtn (PubMed:8530379, PubMed:11294902).
Required for normal mitochondrial morphology and proper mitochondrial fusion during yeast mating (PubMed:23045528).
Miscellaneous
Present with 1080 molecules/cell in log phase SD medium.
Catalytic activity
a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H+ = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
EC:4.1.1.65
Source: Rhea. « Hide
