Products
Flotetuzumab Biosimilar Bispecific scFv Antibody (CD123 × CD3) for Research
Pre-Made Flotetuzumab biosimilar, Bispecific scFv with Crossover, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Flotetuzumab (INN; development code MGD006) is a bispecific antibody designed for the treatment of acute myeloid leukemia.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-218-1mg | 1mg | |
| GMP-Bios-ab-218-10mg | 10mg | |
| GMP-Bios-ab-218-100mg | 100mg | |
| GMP-Bios-ab-218-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Flotetuzumab biosimilar, Bispecific scFv with Crossover, Anti-IL3RA;CD3E Antibody: Anti-CD123/IL3RX/IL3RY/IL3RAY/hIL-3Ra;T3E/TCRE/IMD18 therapeutic antibody |
| INN Name | Flotetuzumab |
| Target | IL3RA;CD3E |
| Format | Bispecific scFv with Crossover |
| Derivation | Bispecific antibody |
| Species Reactivity | Human |
| CH1 Isotype | na |
| VD LC | Kappa;Lambda |
| Highest_Clin_Trial (Jan '20) | Phase-I/II |
| Est. Status | Active |
| 100% SI Structure | None;None |
| 99% SI Structure | None;None |
| 95-98% SI Structure | None;None |
| Year Proposed | 2017 |
| Year Recommended | 2018 |
| Companies | MacroGenics;Servier |
| Conditions Approved | na |
| Conditions Active | Acute myeloid leukaemia;Myelodysplastic syndromes;Precursor cell lymphoblastic leukaemia-lymphoma |
| Conditions Discontinued | na |
| Development Tech | Dual-Affinity Re-Targeting Technology |
About target - IL3RA
1. Protein Interleukin-3 receptor subunit alpha
2. Gene IL3RA
3. Organism Homo sapiens (Human)
Function
This is a receptor for interleukin-3.
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
