Products
Ranibizumab Biosimilar Fab Antibody Fragment (VEGF-A) for Research
Pre-Made Ranibizumab biosimilar, Fab, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ranibizumab (trade name Lucentis among others) is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as bevacizumab. It is an anti-angiogenic that has been approved to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), diabetic retinopathy, and macular edema due to branch retinal vein occlusion or central retinal vein occlusion.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-470-1mg | 1mg | 3090 |
| GMP-Bios-ab-470-10mg | 10mg | |
| GMP-Bios-ab-470-100mg | 100mg | |
| GMP-Bios-ab-470-xmg | ＞100mg |
Product Details
| Products Name (INN Index) | Pre-Made Ranibizumab biosimilar, Fab, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody |
| INN Name | Ranibizumab |
| Target | VEGFA |
| Format | Fab |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | Active |
| 100% SI Structure | 1cz8:HL:YX |
| 99% SI Structure | None |
| 95-98% SI Structure | 1bj1:HL:KJ/6bft:HL:AB |
| Year Proposed | 2004 |
| Year Recommended | 2004 |
| Companies | Genentech;Manhattan Eye Ear & Throat Hospital;Novartis Ophthalmics;University of Bonn |
| Conditions Approved | Choroidal neovascularisation;Degenerative myopia;Diabetic macular oedema;Retinal oedema;Wet age-related macular degeneration;Diabetic retinopathy |
| Conditions Active | Retinopathy of prematurity;Polypoidal choroidal vasculopathy |
| Conditions Discontinued | Retinal telangiectasis |
| Development Tech | na |
About target - VEGFA
1. Protein Vascular endothelial growth factor A
2. Gene VEGFA
3. Organism Homo sapiens (Human)
Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
