Products
Rozibafusp Biosimilar Antibody Fusion Protein (ICOS) for Research
Pre-Made Rozibafusp biosimilar, Whole mAb Fusion, Anti-ICOS Antibody: Anti-AILIM/CD278/CVID1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Rozibafusp alfa (previously AMG 570) is being developed by Amgen and AstraZeneca, for the treatment of systemic lupus erythematosus (SLE) and rheumatoid.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-499-1mg | 1mg | |
| GMP-Bios-ab-499-10mg | 10mg | |
| GMP-Bios-ab-499-100mg | 100mg | |
| GMP-Bios-ab-499-xmg | ＞100mg |
Product Details
| Products Name (INN Index) | Pre-Made Rozibafusp biosimilar, Whole mAb Fusion, Anti-ICOS Antibody: Anti-AILIM/CD278/CVID1 therapeutic antibody |
| INN Name | Rozibafusp |
| Target | ICOS |
| Format | Whole mAb Fusion |
| Derivation | |
| Species Reactivity | Human |
| CH1 Isotype | IgG2 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | 6x4t:BE:DF |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | Amgen |
| Conditions Approved | na |
| Conditions Active | Systemic lupus erythematosus |
| Conditions Discontinued | Rheumatoid arthritis |
| Development Tech | na |
About target - ICOS
1. Protein Inducible T-cell costimulator
2. Gene ICOS
3. Organism Homo sapiens (Human)
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
