Pre-made Talacotuzumab benchmark antibody ( Whole mAb, anti-IL3RA therapeutic antibody, Anti-IL3R/CD123/IL3RX/IL3RY/hIL-3Ra Antibody) for drug discovery and mechanism of action (MOA) research

Cat No.: GMP-Bios-ab-545

Pre-Made Talacotuzumab biosimilar, Whole mAb, Anti-IL3RA Antibody: Anti-IL3R/CD123/IL3RX/IL3RY/hIL-3Ra therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

A humanized IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain or IL3RA) with potential antineoplastic activity. Upon intravenous administration, talacotuzumab binds to and neutralizes CD123.

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GMP-Bios-ab-545-1mg 1mg 3090 Inquiry Inquiry

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Description

Products Name (INN Index) Pre-Made Talacotuzumab biosimilar, Whole mAb, Anti-IL3RA Antibody: Anti-IL3R/CD123/IL3RX/IL3RY/hIL-3Ra therapeutic antibody
INN Name Talacotuzumab
TargetIL3RA
FormatWhole mAb
DerivationHumanized
Species ReactivityHuman
CH1 IsotypeIgG1
VD LCKappa
Highest_Clin_Trial (Jan '20)Phase-III
Est. StatusActive
100% SI Structure4jzj:HL:AB
99% SI StructureNone
95-98% SI StructureNone
Year Proposed2017
Year Recommended2018
CompaniesCSL;Janssen Biotech
Conditions Approvedna
Conditions ActiveMyelodysplastic syndromes
Conditions DiscontinuedAcute myeloid leukaemia;Systemic lupus erythematosus
Development Techna