Pre-made Varlilumab benchmark antibody ( Whole mAb, anti-CD27 therapeutic antibody, Anti-T14/S152/Tp55/TNFRSF7/S152. LPFS2 Antibody) for drug discovery and mechanism of action (MOA) research

Cat No.: GMP-Bios-ab-614

Pre-Made Varlilumab biosimilar, Whole mAb, Anti-CD27 Antibody: Anti-T14/S152/Tp55/TNFRSF7/S152. LPFS2 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Varlilumab (INN; development code CDX-1127) is a monoclonal antibody designed for immunotherapy for solid tumors and hematologic malignancies. It is an anti-CD27 antibody and helps activate T-cells.

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GMP-Bios-ab-614-1mg 1mg 3090 Inquiry Inquiry

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Description

Products Name (INN Index) Pre-Made Varlilumab biosimilar, Whole mAb, Anti-CD27 Antibody: Anti-T14/S152/Tp55/TNFRSF7/S152. LPFS2 therapeutic antibody
INN Name Varlilumab
TargetCD27
FormatWhole mAb
DerivationHuman
Species ReactivityHuman
CH1 IsotypeIgG1
VD LCKappa
Highest_Clin_Trial (Jan '20)Phase-II
Est. StatusActive
100% SI StructureNone
99% SI StructureNone
95-98% SI StructureNone
Year Proposed2014
Year Recommended2015
CompaniesCelldex Therapeutics Inc;Oncothyreon;University of California at San Francisco;University of Virginia
Conditions Approvedna
Conditions ActiveMalignant melanoma;Solid tumours;Non-Hodgkin's lymphoma;Renal cell carcinoma;Glioblastoma
Conditions DiscontinuedHaematological malignancies;Prostate cancer;Breast cancer;Ovarian cancer;Glioma
Development Techna