Human H2AFX/H2A.X/H2A/X ORF/cDNA clone-Lentivirus particle (NM_002105)

Cat. No.: vGMLP000507

Pre-made Human H2AFX/H2A.X/H2A/X Lentiviral expression plasmid for H2AFX lentivirus packaging, H2AFX lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP000507 Human H2AFX Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP000507
Gene Name H2AFX
Accession Number NM_002105
Gene ID 3014
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 432 bp
Gene Alias H2A.X,H2A/X,H2AX
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGTCGGGCCGCGGCAAGACTGGCGGCAAGGCCCGCGCCAAGGCCAAGTCGCGCTCGTCGCGCGCCGGCCTCCAGTTCCCAGTGGGCCGTGTACACCGGCTGCTGCGGAAGGGCCACTACGCCGAGCGCGTTGGCGCCGGCGCGCCAGTGTACCTGGCGGCAGTGCTGGAGTACCTCACCGCTGAGATCCTGGAGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGAATCATCCCCCGCCACCTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCGGCGTGACGATCGCCCAGGGAGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGCCCAAGAAGACCAGCGCCACCGTGGGGCCGAAGGCGCCCTCGGGCGGCAAGAAGGCCACCCAGGCCTCCCAGGAGTACTAA
ORF Protein Sequence MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T55244-Ab Anti-H2AFX monoclonal antibody
    Target Antigen GM-Tg-g-T55244-Ag H2AFX protein
    ORF Viral Vector pGMLP000507 Human H2AFX Lentivirus plasmid
    ORF Viral Vector pGMAP000115 Human H2AFX Adenovirus plasmid
    ORF Viral Vector vGMLP000507 Human H2AFX Lentivirus particle
    ORF Viral Vector vGMAP000115 Human H2AFX Adenovirus particle


    Target information

    Target ID GM-T55244
    Target Name H2AFX
    Gene ID 3014, 15270, 703073, 500987, 101095127, 489372, 531733, 111774230
    Gene Symbol and Synonyms gammaH2ax,H2A.X,H2A/X,H2AFX,H2AX,Hist5-2ax,RGD1566119
    Uniprot Accession P16104
    Uniprot Entry Name H2AX_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000188486
    Target Classification Tumor-associated antigen (TAA)

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]



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