Human F13B/FXIIIB ORF/cDNA clone-Lentivirus particle (NM_001994)

Cat. No.: vGMLP001639

Pre-made Human F13B/FXIIIB Lentiviral expression plasmid for F13B lentivirus packaging, F13B lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP001639 Human F13B Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP001639
Gene Name F13B
Accession Number NM_001994
Gene ID 2165
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 1986 bp
Gene Alias FXIIIB
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGAGGTTGAAAAACCTGACTTTTATCATCATATTGATAATCTCAGGAGAACTCTATGCAGAAGAGAAACCCTGTGGTTTTCCTCATGTGGAAAATGGAAGAATTGCCCAATATTACTATACTTTTAAAAGCTTTTACTTTCCAATGAGCATAGACAAAAAATTGTCATTTTTCTGCTTGGCTGGTTATACCACTGAAAGTGGAAGACAAGAAGAGCAAACCACGTGTACAACAGAAGGCTGGTCTCCAGAGCCAAGGTGCTTCAAAAAATGCACTAAGCCTGACCTGAGTAATGGTTACATCTCTGATGTAAAGTTATTGTATAAAATTCAAGAGAACATGCGTTATGGTTGCGCTTCAGGGTACAAAACCACTGGAGGGAAGGATGAAGAAGTGGTTCAATGTCTCTCTGATGGATGGTCTTCTCAACCAACCTGTAGGAAAGAACATGAAACATGTTTGGCTCCTGAATTATATAATGGAAATTATTCCACAACACAGAAAACATTCAAAGTGAAGGACAAAGTACAATACGAATGTGCTACTGGCTACTACACAGCTGGAGGAAAGAAGACAGAGGAGGTAGAATGTCTCACATACGGATGGTCTCTCACACCAAAATGTACCAAATTAAAGTGCTCTTCTTTAAGATTAATTGAAAATGGTTATTTTCATCCTGTAAAGCAAACCTATGAAGAAGGAGATGTCGTTCAGTTTTTCTGTCATGAAAATTATTATCTAAGTGGATCTGATTTAATTCAATGCTATAACTTTGGTTGGTACCCAGAATCTCCTGTATGCGAAGGAAGAAGAAACAGATGTCCTCCTCCACCTCTGCCCATAAACTCCAAAATTCAAACACATTCAACAACTTATCGTCATGGAGAAATAGTTCATATAGAATGTGAACTTAATTTTGAGATCCATGGGTCAGCAGAAATACGTTGTGAAGATGGAAAATGGACAGAACCTCCAAAATGCATTGAAGGACAGGAGAAGGTAGCCTGTGAGGAACCACCCTTCATTGAAAATGGTGCAGCAAATTTACACTCTAAGATTTATTACAATGGGGATAAAGTGACATATGCATGTAAAAGCGGCTACCTTCTCCATGGATCGAATGAGATAACTTGTAATCGTGGAAAATGGACACTTCCTCCTGAGTGTGTTGAAAATAATGAGAATTGTAAGCATCCTCCTGTTGTAATGAATGGGGCTGTTGCAGACGGGATATTGGCAAGCTATGCAACAGGATCCTCAGTGGAATATAGATGCAATGAATATTACTTACTGAGGGGATCAAAAATATCTCGTTGCGAACAAGGAAAATGGTCATCCCCACCTGTTTGCTTGGAACCATGTACTGTTAATGTGGATTACATGAACAGAAATAACATAGAAATGAAGTGGAAATATGAAGGGAAAGTCTTACATGGAGATTTAATAGATTTTGTATGTAAACAGGGATATGACTTATCTCCATTAACCCCATTGTCTGAATTATCTGTGCAGTGCAACAGAGGAGAAGTGAAATATCCTTTATGTACTAGAAAAGAATCTAAAGGAATGTGCACATCTCCTCCTCTTATTAAACATGGAGTCATTATTAGTTCAACAGTAGACACCTATGAAAATGGCTCTTCAGTAGAATACAGATGTTTTGATCACCATTTCCTAGAAGGATCTAGGGAGGCCTATTGTTTAGATGGAATGTGGACTACACCACCATTGTGTTTAGAGCCATGCACATTATCTTTTACTGAAATGGAAAAGAATAATTTACTTCTGAAATGGGATTTTGACAATAGACCACACATTTTGCATGGTGAATATATTGAGTTTATTTGTAGAGGAGATACTTATCCAGCTGAATTATATATTACTGGATCTATACTTAGAATGCAATGTGACAGAGGGCAGTTAAAATATCCAAGATGTATTCCAAGACAAAGCACTCTGTCTTATCAAGAACCCTTAAGAACATAG
ORF Protein Sequence MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T11947-Ab Anti-F13B/ FXIIIB functional antibody
    Target Antigen GM-Tg-g-T11947-Ag F13B protein
    ORF Viral Vector pGMLP001639 Human F13B Lentivirus plasmid
    ORF Viral Vector vGMLP001639 Human F13B Lentivirus particle


    Target information

    Target ID GM-T11947
    Target Name F13B
    Gene ID 2165, 14060, 711237, 289055, 101091588, 490261, 511483, 102149749
    Gene Symbol and Synonyms Cf-13b,Cf13b,F13B,FXIIIB
    Uniprot Accession P05160
    Uniprot Entry Name F13B_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease breast cancer
    Gene Ensembl ENSG00000143278
    Target Classification Not Available

    This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone.  These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]



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