Rabbit Haemorrhagic Disease Virus antibody and antigen (recombinant protein)

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Diagnostic anti-Rabbit Haemorrhagic Disease Virus antibodies pairs and antigen for animal health (animal Rabbit infectious disease Rabbit Haemorrhagic Disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P004-Ag01	Recombinant Rabbit Haemorrhagic Disease Virus protein	$3090.00
GMP-VT-P004-Ab01	Anti-Rabbit Haemorrhagic Disease Virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P004-Ab02	Anti-Rabbit Haemorrhagic Disease Virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P004-Ag01
Product Name	Recombinant Rabbit Haemorrhagic Disease Virus protein
Pathogen	Rabbit Haemorrhagic Disease Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Rabbit Haemorrhagic Disease Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Rabbit Haemorrhagic Disease Virus level test of animal Rabbit infectious disease with Rabbit Haemorrhagic Disease.
Tag	His
Product description	Recombinant Rabbit Haemorrhagic Disease Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P004-Ab01,GMP-VT-P004-Ab02
Pathogen	Rabbit Haemorrhagic Disease Virus
Product Name	Anti-Rabbit Haemorrhagic Disease Virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Rabbit Haemorrhagic Disease Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rabbit Haemorrhagic Disease Virus antibodies in Rabbit Haemorrhagic Disease Virus level test of animal Rabbit infectious disease with Rabbit Haemorrhagic Disease.
Product description	Anti-Rabbit Haemorrhagic Disease Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rabbit Haemorrhagic Disease Virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Pathogen

Rabbit Haemorrhagic Disease (RHD) is a fatal disease caused by Rabbit Haemorrhagic Disease Virus (RHDV), also known as Rabbit Calicivirus Disease (RCD) or Viral Haemorrhagic Disease (VHD). RHDV is a highly infectious pathogen that affects wild and domestic rabbits. The virus was first identified in China in the 1980s and quickly spread to Europe, causing outbreaks of RHD in the 1990s.

RHDV belongs to the genus Lagovirus in the Caliciviridae family, which also includes other animal caliciviruses and human noroviruses. The virus has a single-stranded RNA genome of approximately 7.5 kilobases that encodes for four major structural proteins: VP60, VP2, VP1, and VP3. The VP60 protein forms the virus capsid, which is responsible for protecting the viral RNA from degradation and facilitating entry into host cells. The other viral proteins are involved in viral replication and assembly.

The virus is structurally complex, with an icosahedral shape and a diameter of approximately 35 nm. It is relatively stable in the environment and can survive for long periods on contaminated surfaces, clothing, and equipment. The virus is highly resistant to physical and chemical disinfection methods, making it challenging to control.

RHDV is primarily spread through direct or indirect contact with contaminated materials, such as feces, urine, or saliva of infected rabbits. The virus can also be transmitted by fleas, ticks, and other arthropods that come into contact with infected animals.

Once RHDV infects a rabbit, the virus replicates rapidly in the liver and spleen, leading to severe damage to these organs and ultimately causing death. Infected rabbits typically develop symptoms within two to three days after exposure, including lethargy, anorexia, and hemorrhagic fever. The disease progresses rapidly, and most infected rabbits die within two to four days.

To diagnose RHDV infections, various diagnostic methods are available, including PCR, ELISA, and immunohistochemistry testing. PCR-based assays are highly sensitive and specific, capable of detecting small amounts of RHDV RNA in clinical samples, such as blood, feces, or tissue samples. ELISA tests are also widely used and can detect antibodies against the virus in infected rabbits. Immunohistochemistry is used to confirm RHDV infection by detecting viral antigens in tissue samples.

Preventing the spread of RHDV infection can be challenging due to the virus's stability and resilience in the environment. However, several preventive measures can help reduce the risk of infection, including strict hygiene practices, quarantine of infected animals, and vaccination. Vaccination with a commercially available inactivated vaccine has proven to be effective in preventing RHDV infections and reducing mortality rates.

In conclusion, RHDV is a highly contagious and fatal pathogen that represents a significant threat to rabbit populations worldwide. Proper diagnosis, control measures, and vaccination programs are essential to mitigate the risk of outbreaks and protect these vulnerable animals.

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