Feline Leukemia Virus antibody and antigen (recombinant protein)

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Diagnostic anti-Feline Leukemia Virus antibodies pairs and antigen for animal health (animal Cat/Feline infectious disease leukemia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P015-Ag01	Recombinant Feline Leukemia Virus protein	$3090.00
GMP-VT-P015-Ab01	Anti-Feline Leukemia Virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P015-Ab02	Anti-Feline Leukemia Virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P015-Ag01
Product Name	Recombinant Feline Leukemia Virus protein
Pathogen	Feline Leukemia Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Leukemia Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Feline Leukemia Virus level test of animal Cat/Feline infectious disease with leukemia.
Tag	His
Product description	Recombinant Feline Leukemia Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P015-Ab01,GMP-VT-P015-Ab02
Pathogen	Feline Leukemia Virus
Product Name	Anti-Feline Leukemia Virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Leukemia Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Leukemia Virus antibodies in Feline Leukemia Virus level test of animal Cat/Feline infectious disease with leukemia.
Product description	Anti-Feline Leukemia Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Leukemia Virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Feline Leukemia Virus (FeLV) is a highly contagious retrovirus that primarily infects domestic cats. It is prevalent, with an estimated 2-3% of all cats in the United States being infected. FeLV is transmitted through bodily fluids, most commonly saliva, and can spread between cats through grooming, biting, or sharing food and water bowls. Kittens can also become infected during gestation or while nursing from an infected mother.

FeLV can cause a range of clinical conditions, including FeLV-associated lymphoma, non-regenerative anemia, immunodeficiency, and various secondary bacterial or viral infections. One of the most common clinical manifestations of FeLV infection is immunosuppression, which can lead to recurrent infections and poor responses to vaccination. Cats infected with FeLV are also at increased risk of developing cancer, particularly lymphoma.

The course of FeLV infection can vary widely among cats, with some animals showing no symptoms for years, while others develop severe illness quickly after infection. Cats that become persistently infected with FeLV may shed the virus intermittently or continuously throughout their lifetime, serving as a source of infection for other cats.

Several diagnostic methods are available to detect FeLV infection, including both serological and molecular techniques. Serological assays, such as enzyme-linked immunosorbent assay (ELISA) and indirect fluorescent antibody (IFA) tests, detect the presence of FeLV-specific antigens or antibodies in a blood sample. These tests are useful for detecting active infection in cats with clinical signs of disease or for screening asymptomatic cats for FeLV exposure.

Molecular methods, such as polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR), target conserved regions within the FeLV genome, such as the gag or env gene, and are highly specific and sensitive for detecting viral nucleic acids. PCR-based tests can detect FeLV infection in asymptomatic cats that are not yet seropositive and can also be used to identify persistently infected cats.

There is no specific treatment for FeLV infection, and management typically involves supportive care and monitoring for secondary infections and complications. Preventative measures, such as vaccination and minimizing contact between infected and non-infected cats, are critical for controlling the spread of FeLV. Vaccination is recommended for all cats, particularly those that have the potential for exposure to infected animals.

In conclusion, Feline Leukemia Virus (FeLV) is a retrovirus that predominantly infects domestic cats and can cause a range of clinical conditions, including lymphoma, anemia, immunodeficiency, and various secondary infections. Diagnostic methods, including serological and molecular techniques, are available to detect FeLV infection. Prevention through vaccination and minimizing contact between infected and non-infected cats is critical for controlling the spread of FeLV.

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