Bovine Herpes Virus 4 antibody and antigen (recombinant protein)

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Diagnostic anti-Bovine Herpes Virus 4 antibodies pairs and antigen for animal health (animal Ovines/Sheep, Caprine/Goat, Bison, Buffalo infectious disease reproductive disease such as endometritis, vulvovaginitis and mastitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P041-Tg001-Ag01	Recombinant Bovine Herpes Virus 4 protein	$3090.00
GMP-VT-P041-Tg001-Ab01	Anti-Bovine Herpes Virus 4 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P041-Tg001-Ab02	Anti-Bovine Herpes Virus 4 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P041-Tg001-Ab03	Anti-Bovine Herpes Virus 4 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P041-Tg001-Ab04	Anti-Bovine Herpes Virus 4 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P041-Tg001-Ag01
Product Name	Recombinant Bovine Herpes Virus 4 protein
Pathogen	Bovine Herpes Virus 4
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Bovine Herpes Virus 4 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Bovine Herpes Virus 4 level test of animal Ovines/Sheep, Caprine/Goat, Bison, Buffalo infectious disease with reproductive disease such as endometritis, vulvovaginitis and mastitis.
Tag	His
Product description	Recombinant Bovine Herpes Virus 4 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P041-Tg001-Ab01,GMP-VT-P041-Tg001-Ab02
Pathogen	Bovine Herpes Virus 4
Product Name	Anti-Bovine Herpes Virus 4 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Bovine Herpes Virus 4 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Herpes Virus 4 antibodies in Bovine Herpes Virus 4 level test of animal Ovines/Sheep, Caprine/Goat, Bison, Buffalo infectious disease with reproductive disease such as endometritis, vulvovaginitis and mastitis.
Product description	Anti-Bovine Herpes Virus 4 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Herpes Virus 4 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P041-Tg001-Ab03,GMP-VT-P041-Tg001-Ab04
Pathogen	Bovine Herpes Virus 4
Product Name	Anti-Bovine Herpes Virus 4 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Bovine Herpes Virus 4 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Herpes Virus 4 antibodies in Bovine Herpes Virus 4 level test of animal Ovines/Sheep, Caprine/Goat, Bison, Buffalo infectious disease with reproductive disease such as endometritis, vulvovaginitis and mastitis.
Product description	Anti-Bovine Herpes Virus 4 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

BoHV-4 is a widely distributed virus that primarily infects cattle and is classified as a member of the Herpesviridae family. This family includes other important viruses like Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), Varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). BoHV-4 comprises an enveloped capsid with a double-stranded DNA genome. It is a large-sized virus measuring about 180-200 nm and 100-120 nm in diameter, respectively, making its measurement relatively smaller than HSV.

BoHV-4 has been shown to be prevalent in many parts of the world, where it can be found in a latent or active form depending on the host's immune system status. The virus can induce clinical as well as subclinical infections and affects the cattle's general health, including weight, productivity, and fertility.

The pathogenesis and severity of BoHV-4 infections are related to various factors such as breed, age, strain, and immunological status. Within the herd, BoHV-4 can be transmitted through direct and indirect contact. Transmission occurs when animals come into contact with nasal discharge and other bodily fluids from infected animals. Indirect transmission may occur via contaminated instruments and gear and bedding among others.

BoHV-4's main genes and proteins have been characterized, and UL21 and ORF20 are considered the most important. UL21 is a tegument protein that plays a crucial role in virus replication, while ORF20, a viral glycoprotein, helps the virus bind to and enter the host cell during infection. Although other proteins may contribute to BoHV-4 pathogenesis, their roles are yet to be fully understood.

BoHV-4 is known to cause a range of diseases in cattle such as respiratory disease, abortion, mastitis, and genital infections. The severity of the disease varies depending on various factors such as age, breed, and immune status. In adult cows, BoHV-4 can cause respiratory disease characterized by fever, coughing, nasal discharge, and general malaise. BoHV-4 can also cause vulvovaginitis in heifers, and genital infections in bulls, including spermatic cord infections and orchitis. BoHV-4 is also associated with abortions in pregnant cattle, where it contributes to a significant economic loss to farmers by hindering milk production and reducing reproduction rates.

Several laboratory methods have been developed for the diagnosis of BoHV-4 infections. These methods include virus isolation, polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA). Virus isolation involves culturing BoHV-4 from infected tissues or body fluids. PCR and ELISA are highly sensitive and specific methods that detect particular gene sequences or antibodies against BoHV-4. PCR targets specific genes, such as UL21, while ELISA typically measures IgG antibodies against BoHV-4.

In conclusion, BoHV-4 is an important pathogen in cattle that causes a range of clinical and subclinical diseases. It is a member of the Herpesviridae family and is characterised by its double-stranded DNA genome surrounded by an envelope. The virus's epidemiology and pathogenesis are still being investigated, but its clinical significance makes it important to develop effective diagnostic and control methods.

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