Rotavirus A antibody and antigen (recombinant protein)

Diagnostic anti-Rotavirus A antibodies pairs and antigen for animal health (animal Ovines/Sheep, Caprine/Goat infectious disease gastroenteritis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P044-Tg001-Ag01 Recombinant Rotavirus A protein $3090.00
GMP-VT-P044-Tg001-Ab01 Anti-Rotavirus A mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P044-Tg001-Ab02 Anti-Rotavirus A mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P044-Tg001-Ab03 Anti-Rotavirus A human monoclonal antibody (mAb) $3090.00
GMP-VT-P044-Tg001-Ab04 Anti-Rotavirus A human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P044-Tg001-Ag01
Product Name Recombinant Rotavirus A protein
Pathogen Rotavirus A
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Rotavirus A antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Rotavirus A level test of animal Ovines/Sheep, Caprine/Goat infectious disease with gastroenteritis.
Tag His
Product description Recombinant Rotavirus A proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P044-Tg001-Ab01,GMP-VT-P044-Tg001-Ab02
Pathogen Rotavirus A
Product Name Anti-Rotavirus A mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Rotavirus A antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rotavirus A antibodies in Rotavirus A level test of animal Ovines/Sheep, Caprine/Goat infectious disease with gastroenteritis.
Product description Anti-Rotavirus A mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rotavirus A antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P044-Tg001-Ab03,GMP-VT-P044-Tg001-Ab04
Pathogen Rotavirus A
Product Name Anti-Rotavirus A human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Rotavirus A antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rotavirus A antibodies in Rotavirus A level test of animal Ovines/Sheep, Caprine/Goat infectious disease with gastroenteritis.
Product description Anti-Rotavirus A mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Data / case study


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    Pathogen Information


    Rotavirus A is a viral pathogen that infects the gastrointestinal tract in humans, causing severe gastroenteritis with symptoms such as vomiting, diarrhea, fever, and dehydration. Rotavirus A belongs to the Reoviridae family and is a double-stranded RNA virus. It is composed of an outer layer made up of VP4 and VP7 proteins and an inner core that contains the viral genome and structural proteins such as VP1, VP2, VP3, and VP6.

    The VP4 protein is responsible for viral attachment to the host cell, while the VP7 protein plays a role in inducing neutralizing antibodies that can provide immunity against subsequent infection. The VP6 protein forms the inner capsid shell around the genomic RNA segments, making it a major target for diagnostic assays. The NSP4 protein, which is not part of the viral particle, but is released during the replication cycle of the virus and plays a role in intracellular signaling and pathogenesis.

    Rotavirus A primarily infects humans, particularly young children under the age of five. It is estimated that rotavirus infections are responsible for about 200,000 deaths annually worldwide, with most of these occurring in developing countries. Infants and young children who are malnourished or have weakened immune systems are at increased risk of severe disease and death from rotavirus infections.

    Transmission of Rotavirus A occurs through the fecal-oral route, primarily via contaminated food or water, or through contact with infected individuals or objects. The virus can be shed in feces for several weeks after infection, making good hygiene practices essential for limiting its spread.

    Diagnosis of Rotavirus A can be challenging, as the symptoms of rotavirus gastroenteritis can be similar to those of other gastrointestinal pathogens. However, various diagnostic methods are available to detect and identify Rotavirus A infections. One of the most commonly employed methods is reverse transcription-polymerase chain reaction (RT -PCR), which amplifies viral RNA segments that can be detected by DNA probes or sequencing. Other methods include enzyme-linked immunosorbent assay (ELISA), rapid immunochromatographic assays, and electron microscopy.

    Treatment of Rotavirus A infections is primarily supportive, with a focus on replacing lost fluids and electrolytes to prevent dehydration and maintaining adequate nutrition. While there are no specific antiviral drugs for rotavirus infections, several vaccines have been developed that have proven highly effective in preventing severe disease and death from rotavirus gastroenteritis.

    In conclusion, while Rotavirus A may seem like an ordinary stomach bug, it can lead to severe disease, especially in infants and young children. Careful hygiene practices, fast diagnosis, appropriate treatment, and vaccination, serve as critical ways to reduce the spread of Rotavirus A and its devastating impact. It is essential to continue exploring new ways to combat this pathogen and improve global health outcomes.



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.