Babesia caballi antibody and antigen (recombinant protein)

Diagnostic anti-Babesia caballi antibodies pairs and antigen for animal health (animal Equine/Horse infectious disease Equine/Horse Piroplasmosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P143-Ag01 Recombinant Babesia caballi protein $3090.00
GMP-VT-P143-Ab01 Anti-Babesia caballi mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P143-Ab02 Anti-Babesia caballi mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P143-Ag01
Product Name Recombinant Babesia caballi protein
Pathogen Babesia caballi
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Babesia caballi antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Babesia caballi level test of animal Equine/Horse infectious disease with Equine/Horse Piroplasmosis.
Tag His
Product description Recombinant Babesia caballi proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P143-Ab01,GMP-VT-P143-Ab02
Pathogen Babesia caballi
Product Name Anti-Babesia caballi mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Babesia caballi antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Babesia caballi antibodies in Babesia caballi level test of animal Equine/Horse infectious disease with Equine/Horse Piroplasmosis.
Product description Anti-Babesia caballi mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Babesia caballi antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Babesia caballi is a protozoan parasite of the genus Babesia, which is responsible for causing equine piroplasmosis, equine babesiosis, and equine hemolytic anemia. This pathogen is commonly referred to as Babesia or Piroplasmosis and is known to primarily infect horses. The disease has a worldwide distribution with various strains observed in different geographical locations.

    Babesia caballi belongs to the phylum Apicomplexa, class Aconoidasida, order Piroplasmida, and family Babesiidae. It is a small, pear-shaped, single-celled organism that can be detected under a microscope. The genome of Babesia caballi consists of a single circular DNA molecule that is about 8.2 Mb in size. The genome sequence has provided crucial information on the life cycle, virulence, and pathogenesis of the pathogen.

    The primary protein associated with this pathogen is rhoptry-associated protein 1 (RAP-1), which plays a critical role in host cell invasion and immune evasion. RAP-1 is also involved in the development of protective immunity against Babesia caballi infections. Other virulence factors, including apical membrane antigen-1 (AMA-1), actin, thrombospondin-related adhesive protein (TRAP), and merozoite surface proteins (MSPs), are also expressed by the pathogen during different stages of the life cycle.

    Babesia caballi selectively infects horses and is transmitted by tick bites. The main tick species involved in the transmission of B. caballi include Dermacentor spp. and Hyalomma spp. The parasite infects erythrocytes, leading to their destruction and the development of anemia. The infection can also damage organs, such as the liver, spleen, and kidneys. Clinical signs of Babesia caballi infection include fever, anemia, lethargy, jaundice, and weight loss.

    Diagnosis of Babesia caballi infection is traditionally achieved by microscopic examination of blood samples for the presence of intraerythrocytic parasites. However, this method has some limitations, including low sensitivity and specificity. Other serological tests, such as enzyme-linked immunosorbent assays (ELISAs), can detect antibodies against the pathogen and are more sensitive than microscopy. Nucleic acid-based tests such as polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) can also be used to diagnose Babesia caballi infections. These methods target specific genes or proteins such as the 18S ribosomal RNA gene, cytochrome b gene, and heat shock protein 70. These tests are highly sensitive and specific and can detect the pathogen even in asymptomatic carriers.

    In conclusion, Babesia caballi is a protozoan parasite that selectively infects horses and is transmitted by tick bites. The pathogen infects erythrocytes and causes various clinical signs, including fever, anemia, lethargy, and weight loss. Diagnosis of Babesia caballi infection is traditionally achieved by microscopic examination of blood samples. However, newer methods such as PCR and LAMP are highly sensitive and specific and can detect the pathogen even in asymptomatic carriers. The genome sequence of Babesia caballi provides crucial information on the life cycle, virulence, and pathogenesis of the pathogen and assists in the development of more effective diagnostic tools and vaccines.



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