neurofilament light chain (NFL) antibody and antigen (Recombinant protein)

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Diagnostic neurofilament light chain (NFL) antibodies (anti-neurofilament light chain, anti-NFL) and antigens (recombinant neurofilament light chain (NFL) protein) for Neurodegenerative diseases NFL detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-NFL-Ag01	Recombinant human NFL Protein	$3090.00
GMP-h-NFL-Ab01	Anti-human NFL mouse monoclonal antibody (mAb)	$1953.00
GMP-h-NFL-Ab02	Anti-human NFL mouse monoclonal antibody (mAb)	$1953.00
GMP-h-NFL-Ab03	Anti-human NFL human monoclonal antibody (mAb)	$1953.00
GMP-h-NFL-Ab04	Anti-human NFL human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-NFL-Ag01
Product Name	Recombinant human NFL Protein
Target/Biomarker	neurofilament light chain (NFL)
Alias of Target/Biomarker	CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	neurofilament light chain (NFL) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
Products description	Recombinant Human neurofilament light chain (NFL) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-NFL-Ab01,GMP-h-NFL-Ab02
Product Name	Anti-human NFL mouse monoclonal antibody (mAb)
Target/Biomarker	neurofilament light chain (NFL)
Alias of Target/Biomarker	CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human NFL mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-NFL-Ab03,GMP-h-NFL-Ab04
Product Name	Anti-human NFL human monoclonal antibody (mAb)
Target/Biomarker	neurofilament light chain (NFL)
Alias of Target/Biomarker	CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human NFL mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3). Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L. Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD).

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