neurofilament light chain (NFL) antibody and antigen (Recombinant protein)
Diagnostic neurofilament light chain (NFL) antibodies (anti-neurofilament light chain, anti-NFL) and antigens (recombinant neurofilament light chain (NFL) protein) for Neurodegenerative diseases NFL detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.
Go to Neurodegenerative diseases diagnostics products collection >>
Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-h-NFL-Ag01 | Recombinant human NEFL/NFL/NF68 Protein | 3090 |
GMP-h-NFL-Ab01 | Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) | 1953 |
GMP-h-NFL-Ab02 | Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) | 1953 |
GMP-h-NFL-Ab03 | Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) | 1953 |
GMP-h-NFL-Ab04 | Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) | 1953 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. of Products | GMP-h-NFL-Ag01 |
Product Name | Recombinant human NEFL/NFL/NF68 Protein |
Target/Biomarker | neurofilament light chain(NFL) |
Alias of Target/Biomarker | CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110 |
Expression platform | mammalian |
Isotypes | Recombinant Antigen |
Bioactivity validation | neurofilament light chain (NFL) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation. |
Products description | Recombinant human NEFL/NFL/NF68 Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS,PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. of Products | GMP-h-NFL-Ab01, GMP-h-NFL-Ab02 |
Product Name | Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) |
Target/Biomarker | neurofilament light chain(NFL) |
Alias of Target/Biomarker | CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110 |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation. |
Tag | mFc |
Products description | Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS,PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. of Products | GMP-h-NFL-Ab03, GMP-h-NFL-Ab04 |
Product Name | Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) |
Target/Biomarker | neurofilament light chain(NFL) |
Alias of Target/Biomarker | CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110 |
Expression platform | CHO |
Isotypes | Human lgG1 |
Bioactivity validation | Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation. |
Tag | hFc |
Products description | Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS,PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Target/Biomarker information
Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3). Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L. Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD).
About GDU
GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.
Comments