neurofilament light chain (NFL) antibody and antigen (Recombinant protein)

Diagnostic neurofilament light chain (NFL) antibodies (anti-neurofilament light chain, anti-NFL) and antigens (recombinant neurofilament light chain (NFL) protein) for Neurodegenerative diseases NFL detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No. Description US $ Price (per mg)
GMP-h-NFL-Ag01 Recombinant human NEFL/NFL/NF68 Protein 3090
GMP-h-NFL-Ab01 Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) 1953
GMP-h-NFL-Ab02 Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) 1953
GMP-h-NFL-Ab03 Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) 1953
GMP-h-NFL-Ab04 Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) 1953

Size: 1mg | 10mg | 100mg



Product Description

Cat No. of Products GMP-h-NFL-Ag01
Product Name Recombinant human NEFL/NFL/NF68 Protein
Target/Biomarker neurofilament light chain(NFL)
Alias of Target/Biomarker CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform mammalian
Isotypes Recombinant Antigen
Bioactivity validation neurofilament light chain (NFL) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation.
Products description Recombinant human NEFL/NFL/NF68 Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products GMP-h-NFL-Ab01, GMP-h-NFL-Ab02
Product Name Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb)
Target/Biomarker neurofilament light chain(NFL)
Alias of Target/Biomarker CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation.
Tag mFc
Products description Anti-human NEFL/NFL/NF68 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products GMP-h-NFL-Ab03, GMP-h-NFL-Ab04
Product Name Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb)
Target/Biomarker neurofilament light chain(NFL)
Alias of Target/Biomarker CMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD),Huntington's Disease (HD)) and related syndrome evaluation.
Tag hFc
Products description Anti-human NEFL/NFL/NF68 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker information

    Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3). Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L. Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD).



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    Comments


    Elizabeth Moore 2023-01-21 14:59:49
    Neurofilament Light Chain reagent from Genemedi is ideal for diagnostic assays due to the reagent's stability and reliable data output, which is ideal for ELISA and other related techniques.

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