AAV2 variant (Y444F) vector system (retina-validated AAV expression and packaging plasmid system)

GeneMedi (GM) AAV2 variant (Y444F) Vector system is including: 1) AAV2 variant (Y444F) Rep-Cap plasmid (AAV2 variant (Y444F)-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV2 variant (Y444F) particle in 293T cell line in high titer using GeneMedi's AAV2 variant (Y444F) Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

The tissue tropism of AAV2 variant (Y444F) vector has been validated in retina (retinal ganglion cells) by both intravitreal injection and sub-retinal injection., with potential applications in retina gene therapy.

Target products collectionGo to AAV vector system >>



Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-PK03 AAV2 variant(Y444F)Vector System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 3024
P-PK03 AAV2 variant(Y444F)Vector System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK03 AAV2 variant(Y444F)Vector System
1. AAV2 variant (Y444F) Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK03-Kan AAV2 variant(Y444F)Vector System(Kan resistance)
1. AAV2 variant (Y444F) Rep-Cap Plasmid(Kan resistance), 10mg
2. AAV Helper Plasmid(Kan resistance), 10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks.
P-RC03 AAV2 variant(Y444F)Rep-Cap Plasmid
Academic 1719
P-RC03 AAV2 variant(Y444F)Rep-Cap Plasmid
Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC03 AAV2 variant(Y444F)Rep-Cap Plasmid
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC03-Kan AAV2 variant(Y444F)Rep-Cap Plasmid(Kan resistance)
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production&lification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain CELL 2018/6/14
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15 Journal of Hepatology 2023/5/20
SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)–Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation Circulation 2020/3/24
Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus signal transduction and targeted therapy 2022/2/18
shear stress-induced cellular senescence blunts liver regeneration through Notch-Sirt1-P21/P16 axis Hepatology 2021/10/23
[PDF] TIMP2 ameliorates blood–brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-Cadherin internalization JOURNAL OF CLINICAL INVESTIGATION 2023/11/28
Epigenetic controls of Sonic hedgehog guarantee fidelity of epithelial adult stem cells trajectory in regeneration Science Advances 2022/7/22
FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes npj Regenerative Medicine 2022/6/24
KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function Autophagy 2023/9/15
SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation Journal of Experimental & Clinical Cancer Research 2023/9/8


Validation data

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Associated products and services


Products & Service Products & Service Information
AAV Packaging service Detail
Promise-ORF™ viral CDNA library Detail
Plasmid DNA Rapid Preparation Service Detail