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AAV8-1m vector system (retina-validated AAV expression and packaging plasmids)
GeneMedi (GM) AAV8-1m Vector system is including: 1) AAV8-1m Rep-Cap plasmid (AAV8-1m-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).
You can produce AAV8-1m particle in 293T cell line in high titer using GeneMedi's AAV8-1m Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.
The tissue tropism of AAV8 variant(Y733F) vector has been validated in retina with higher transduction efficiency and more rapid onset of expression in photoreceptor cells by both intravitreal injection and sub-retinal injection with potential applications in retina gene therapy.
Go to AAV
vector system
>>Product Description
| Cat.NO | Product Name | Organization Type | Price(In USD) | ||
|---|---|---|---|---|---|
| P-PK10 | AAV8-1m Vector System 1. AAV8-1m Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Academic | 3024 | ||
| P-PK10 | AAV8-1m Vector System 1. AAV8-1m Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Industry R&D (excluding CRO&CDMO&CXO) |
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| P-PK10 | AAV8-1m Vector System 1. AAV8-1m Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug |
CRO&CDMO& CXO&CMC& Manufacturing company |
|||
| P-PK10-Kan | AAV8-1m Vector System(Kan resistance) 1. AAV8-1m Rep-Cap Plasmid(Kan resistance), 10mg 2. AAV Helper Plasmid(Kan resistance), 10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks. | |||||
| P-RC10 | AAV8-1m Rep-Cap
Plasmid
|
Academic | 1719 | ||
| P-RC10 | AAV8-1m Rep-Cap
Plasmid
| Industry R&D (excluding CRO&CDMO&CXO) |
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| P-RC10 | AAV8-1m Rep-Cap
Plasmid
| CRO&CDMO& CXO&CMC& Manufacturing company |
|||
| P-RC10-Kan | AAV8-1m Rep-Cap
Plasmid(Kan resistance)
|
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks. | |||||
| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | |||||
|
Terms of sale: For Seed (5ug): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party. For plasmid production&lification (≥10mg): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party. |
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Citation
| Title | Publication | Date |
|---|---|---|
| LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling | Molecular Cancer | 2023/8/4 |
| [PDF] GDF15 is a major determinant of ketogenic diet-induced weight loss | cell metabolism | 2023/12/5 |
| Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline | Cell Metabolism | 2020/3/3 |
| CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications | Nature Communications | 2023/8/28 |
| Wild- type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway | SCIENCE TRANSLATIONAL MEDICINE | 2023/12/13 |
| PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma | Cell death and differentiation | 2021/1/19 |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression | Nature communications | 2021/1/8 |
| The immunoproteasome catalytic ?5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation | SCIENCE ADVANCES | 2019/5/8 |
| SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes | Autophagy | 2022/8/1 |
| Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer | Journal of Experimental & Clinical Cancer Research | 2022/10/5 |
Validation data
Figure. Selected transduction results of AAV in vitro (in 293T cell line)
Virus and titer: AAV1/AAV6/AAV8/AAV-Rh10/AAV-DJ/AAV9-GFP, 1×1012 vg/ml
Cells: HEK-293T
MOI: MOI=1×104
Determine assay: 36 hours post infection, immunofluorescence microscopy
Associated products and services
| Products & Service | Products & Service Information |
|---|---|
| AAV Packaging service | Detail |
| Promise-ORF™ viral CDNA library | Detail |
| Plasmid DNA Rapid Preparation Service | Detail |
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