AAV-PHP.eB vector system (AAV-PHP.eB expression and packaging plasmid system, across the blood-brain barrier(BBB) ) (Amp and Kanamycin) (GeneMedi Owned)

GeneMedi (GM) AAV-PHP.eB Vector system is including: 1) AAV-PHP.eB Rep-Cap plasmid (AAV-PHP.eB-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV-PHP.eB particle in 293T cell line in high titer using GeneMedi's AAV-PHP.eB Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).

GeneMedi offers both Ampicillin (Amp) resistance and Kanamycin (Kan) resistance for the AAV Rep-Cap Plasmids, AAV expression Plasmids and AAV helper Plasmid.

Target products collectionGo to AAV vector system >>



Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-PK20 AAV-PHP.eB Vector System (Amp resistance)
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 3024
P-PK20 AAV-PHP.eB Vector System (Amp resistance)
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK20 AAV-PHP.eB Vector System (Amp resistance)
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK20 AAV-PHP.eB Vector System (Amp resistance)
1. AAV-PHP.eB Rep-Cap Plasmid, ≥10mg
2. AAV Helper Plasmid, ≥10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01-Kan), ≥10mg
 All
P-PK20-Kan AAV-PHP.eB Vector System (Kan resistance)
1. AAV-PHP.eB Rep-Cap Plasmid (Kan resistance) , ≥10mg
2. AAV Helper Plasmid (Kan resistance) , ≥10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), ≥10mg
 All
P-RC20 AAV-PHP.eB Rep-Cap Plasmid (Amp resistance)
Size：5ug 		Academic 1719
P-RC20 AAV-PHP.eB Rep-Cap Plasmid (Amp resistance)
Size：5ug 		Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC20 AAV-PHP.eB Rep-Cap Plasmid (Amp resistance)
Size：5ug 		CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC20 AAV-PHP.eB Rep-Cap Plasmid (Amp resistance)
Size：≥10mg 		All
P-RC20-Kan AAV-PHP.eB Rep-Cap Plasmid(Kan resistance)
Size：≥10mg 		All
GeneMedi offers both seed and amplification services for the Amp-resistant AAV Vector System.
GeneMedi only offers amplification services and do not provide seed for the Kan-resistant AAV Vector System currently.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production& amplification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L Signal Transduction and Targeted Therapy 2023/10/11
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer Molecular Cancer 2020/3/12
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice Nature Metabolism 2022/11/18
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis Nature Communications 2022/12/19
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy Advanced science 2021/11/16
The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression Cancer communications 2022/7/18
Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects Acta Pharmaceutica Sinica B 2022/12/14
Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease Sci Adv 2020/6/29
Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease Theranostics 2024/1/1


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Associated products and services


Products & Service Products & Service Information
AAV Packaging service Detail
Promise-ORF™ viral CDNA library Detail
Plasmid DNA Rapid Preparation Service Detail