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AAV-PHP.S Rep-Cap plasmid (specific serotype across (blood-brain barrier(BBB) AAV RC plamid)
GeneMedi's AAV-PHP.S Rep-Cap plasmid supplies the AAV2 Rep (replication) proteins and the AAV-PHP.S capsid protein.
You can produce AAV-PHP.S particle in 293T cell line in high titer using GeneMedi's AAV-PHP.S Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.
With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).
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vector system
>>Product Description
| Cat.NO | Product Name | Organization Type | Price(In USD) | ||
|---|---|---|---|---|---|
| P-RC21 | AAV-PHP.S Rep-Cap Plasmid | Academic | 1308 | ||
| P-RC21 | AAV-PHP.S Rep-Cap Plasmid | Industry R&D (excluding CRO&CDMO&CXO) |
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| P-RC21 | AAV-PHP.S Rep-Cap Plasmid |
CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-RC21-Kan | AAV-PHP.S Rep-Cap Plasmid(Kan resistance) |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks. | |||||
| P-PK21 | AAV-PHP.S Vector
System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug |
Academic | 2664 | ||
| P-PK21 | AAV-PHP.S Vector
System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Industry R&D (excluding CRO&CDMO&CXO) |
|||
| P-PK21 | AAV-PHP.S Vector
System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | CRO&CDMO& CXO&CMC& Manufacturing company |
|||
| P-PK21-Kan | AAV-PHP.S Vector
System(Kan resistance)
1. AAV-PHP.S Rep-Cap Plasmid(Kan resistance), 10mg 2. AAV Helper Plasmid(Kan resistance), 10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks. | |||||
| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | |||||
|
Terms of sale: For Seed (5ug): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party. For plasmid production&lification (≥10mg): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party. |
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Citation
| Title | Publication | Date |
|---|---|---|
| The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation | Signal Transduction and Targeted Therapy | 2023/9/21 |
| Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration | Molecular Cancer | 2018/10/6 |
| Cobaltosic oxide-polyethylene glycol-triphenylphosphine nanoparticles ameliorate the acute-to-chronic kidney disease transition by inducing BNIP3-mediated mitophagy | Kidney international | |
| TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage | Nature communications | 2022/12/2 |
| AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes | Advanced Science | 2021/2/1 |
| The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression | Cancer Communications | 2022/7/18 |
| Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer | Acta Pharmaceutica Sinica B | 2022/10/28 |
| Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells | Journal for ImmunoTherapy of Cancer | 2021/12/1 |
| Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression | Journal of Sport and Health Science | 2022/10/29 |
| Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles | Theranostics | 2024/1/1 |
Validation data
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Associated products and services
| Products & Service | Products & Service Information |
|---|---|
| AAV Packaging service | Detail |
| Promise-ORF™ viral CDNA library | Detail |
| Plasmid DNA Rapid Preparation Service | Detail |
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