AAV-SIG vector system (AAV-SIG expression system, AAV-SIG packaging plasmid system)

GeneMedi's AAV-SIG Vector System (AAV serotype SIG helper-free packaging plasmids system) is including AAV-SIG Rep-Cap plamid (AAV-SIG-RC plasmid, or called AAV-RC1 plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).

GeneMedi's AAV expression vectors have been inserted with differernt expression cassettes, containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference ). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.

AAV-SIG Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV-SIG capsid protein.

The tissue tropism of AAV-SIG vector has been validated in endothelium, with potential applications in tissue-specific gene therapy.