Products
Lorvotuzumab Mertansine Biosimilar Antibody-Drug Conjugate (CD56) for Research
Pre-made Lorvotuzumab Mertansine benchmark antibody (Whole mAb ADC, anti-NCAM1 therapeutic antibody, Anti-CD56/MSK39/NCAM Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Lorvotuzumab mertansine (IMGN91) is an antibody-drug conjugate. It comprises the CD56-binding antibody, lorvotuzumab (huN91), with a maytansinoid cell-killing agent, DM1, attached using a disulfide linker, SPP. (When DM1 is attached to an antibody with the SPP linker, it is mertansine; when it is attached with the thioether linker, SMCC, it is emtansine.)
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-899-1mg | 1mg | |
| GMP-Bios-INN-899-10mg | 10mg | |
| GMP-Bios-INN-899-100mg | 100mg | |
| GMP-Bios-INN-899-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Lorvotuzumab Mertansine Biosimilar, Whole Mab Adc, Anti-Ncam1 Antibody: Anti-CD56/MSK39/NCAM therapeutic antibody Drug Conjugate |
| INN Name | Lorvotuzumab Mertansine |
| Target | NCAM1 |
| Format | Whole mAb ADC |
| Derivation | Humanized |
| Species Reactivity | human |
| CH1 Isotype | IgG1 - kappa |
| VD LC | IgG1 - kappa |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | ImmunoGen Inc. (Cambridge MA USA) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - NCAM1
1. Protein Neural cell adhesion molecule 1
2. Gene NCAM1
3. Organism Homo sapiens (Human)
Function
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
(Microbial infection) Acts as a receptor for rabies virus.
(Microbial infection) Acts as a receptor for Zika virus.
