Products
Odulimomab Biosimilar F(ab')2 Antibody Fragment (CD11a) for Research
Pre-made Odulimomab benchmark antibody (Fab Fusion, anti-ITGAL therapeutic antibody, Anti-CD11A/LFA-1/LFA1A Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Odulimomab is an investigational drug for the prevention of transplant rejection[1][2] and for the treatment of various immunological diseases.[3][4]
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-INN-931-1mg | 1mg | 3090 |
| GMP-Bios-INN-931-10mg | 10mg | |
| GMP-Bios-INN-931-100mg | 100mg | |
| GMP-Bios-INN-931-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Odulimomab Biosimilar, Fab Fusion, Anti-Itgal Antibody: Anti-CD11A/LFA-1/LFA1A therapeutic antibody |
| INN Name | Odulimomab |
| Target | ITGAL |
| Format | Fab Fusion |
| Derivation | Mus musculus |
| Species Reactivity | human |
| CH1 Isotype | F(ab')2 - G1 - nd |
| VD LC | F(ab')2 - G1 - nd |
| Highest_Clin_Trial (Jan '20) | |
| Est. Status | |
| 100% SI Structure | |
| 99% SI Structure | |
| 95-98% SI Structure | |
| Year Proposed | |
| Year Recommended | |
| Companies | Pasteur M (Lyon France) |
| Conditions Approved | |
| Conditions Active | |
| Conditions Discontinued | |
| Development Tech | 0 |
About target - ITGAL
1. Protein Integrin alpha-L
2. Gene ITGAL
3. Organism Homo sapiens (Human)
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
