Products
Cofetuzumab Biosimilar Antibody-Drug Conjugate (PTK7) for Research
Pre-Made Cofetuzumab biosimilar, Whole mAb ADC, Anti-PTK7 Antibody: Anti-CCK-4/CCK4 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Cofetuzumab pelidotin (INN; development code PF-06647020) is an experimental antibody-drug conjugate in development for the treatment of cancer. It was created by Stemcentrx and is being developed by Pfizer. The drug is an anti-PTK7 monoclonal antibody linked to auristatin-0101, an auristatin microtubule inhibitor.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-115-1mg | 1mg | |
| GMP-Bios-ab-115-10mg | 10mg | |
| GMP-Bios-ab-115-100mg | 100mg | |
| GMP-Bios-ab-115-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Cofetuzumab biosimilar, Whole mAb ADC, Anti-PTK7 Antibody: Anti-CCK-4/CCK4 therapeutic antibody |
| INN Name | Cofetuzumab |
| Target | PTK7 |
| Format | Whole mAb ADC |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2017 |
| Year Recommended | 2018 |
| Companies | Stemcentrx;Indiana University;Pfizer;Stemcentrx |
| Conditions Approved | na |
| Conditions Active | Non-small cell lung cancer;Solid tumours |
| Conditions Discontinued | Breast cancer |
| Development Tech | na |
About target - PTK7
1. Protein Inactive tyrosine-protein kinase 7
2. Gene PTK7
3. Organism Homo sapiens (Human)
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
