Products
Crotedumab Biosimilar Monoclonal Antibody (Glucagon Receptor) for Research
Pre-Made Crotedumab biosimilar, Whole mAb, Anti-GCGR Antibody: Anti-GGR/GL-R/MVAH therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Crotedumab (REGN1193) (INN) is a humanized monoclonal antibody designed for the treatment of diabetes.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-124-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Crotedumab biosimilar, Whole mAb, Anti-GCGR Antibody: Anti-GGR/GL-R/MVAH therapeutic antibody |
| INN Name | Crotedumab |
| Target | GCGR |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG4 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2015 |
| Year Recommended | 2016 |
| Companies | Regeneron Pharmaceuticals;Sanofi |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Type 2 diabetes mellitus |
| Development Tech | na |
About target - GCGR
1. Protein Glucagon receptor
2. Gene GCGR
3. Organism Homo sapiens (Human)
Function
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
