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Flanvotumab Biosimilar Monoclonal Antibody (TYRP1) for Research
Pre-Made Flanvotumab biosimilar, Whole mAb, Anti-TYRP1 Antibody: Anti-TRP/CAS2/CATB/GP75/OCA3/TRP1/TYRP/b-PROTEIN therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Flanvotumab, also known as IMC-20D7S, is a human monoclonal antibody designed for the treatment of melanoma. It targets TYRP1.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-216-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Flanvotumab biosimilar, Whole mAb, Anti-TYRP1 Antibody: Anti-TRP/CAS2/CATB/GP75/OCA3/TRP1/TYRP/b-PROTEIN therapeutic antibody |
| INN Name | Flanvotumab |
| Target | TYRP1 |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2011 |
| Year Recommended | 2012 |
| Companies | ImClone Systems;Eli Lilly |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Malignant melanoma |
| Development Tech | na |
About target - TYRP1
1. Protein 5,6-dihydroxyindole-2-carboxylic acid oxidase
2. Gene TYRP1
3. Organism Homo sapiens (Human)
Function
Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458).
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions, but not in the presence of Zn2+ (PubMed:28661582).
May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).
Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Caution
The precise function of this protein in melanin biosynthesis is still under debate. DHICA oxidase activity is controversial (PubMed:9758418, PubMed:28661582). Lacks DHICA oxidase activity (PubMed:9758418). Has DHICA oxidase activity in the presence of Cu2+, but lacks DHICA oxidase activity with Zn2+ (PubMed:28661582).
Cofactor
Cu2+, Zn2+
Note: Contains bound zinc ions after heterologous expression in insect cells, giving rise to a protein that lacks DHICA oxidase activity.
Activity regulation
The activity depends critically on the nature of the bound metal ion. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the presence of bound Cu2+ ions, but lacks activity in the presence of bound Zn2+ ions.
Pathway: melanin biosynthesis
This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.
