Products
Glenzocimab Biosimilar Fab Antibody Fragment (GPVI) for Research
Pre-Made Glenzocimab biosimilar, Fab, Anti-GP6 Antibody: Anti-BDPLT11/GPIV/GPVI therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-247-1mg | 1mg | 3090 |
| GMP-Bios-ab-247-10mg | 10mg | |
| GMP-Bios-ab-247-100mg | 100mg | |
| GMP-Bios-ab-247-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Glenzocimab biosimilar, Fab, Anti-GP6 Antibody: Anti-BDPLT11/GPIV/GPVI therapeutic antibody |
| INN Name | Glenzocimab |
| Target | GP6 |
| Format | Fab |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | Acticor Biotech |
| Conditions Approved | na |
| Conditions Active | Stroke;COVID-19 |
| Conditions Discontinued | na |
| Development Tech | na |
About target - GP6
1. Protein Platelet glycoprotein VI
2. Gene GP6
3. Organism Homo sapiens (Human)
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
