Products
Imaprelimab Biosimilar Monoclonal Antibody (MCAM) for Research
Pre-Made Imaprelimab biosimilar, Whole mAb, Anti-MCAM Antibody: Anti-CD146/HEMCAM/METCAM8/MelCAM therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-266-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Imaprelimab biosimilar, Whole mAb, Anti-MCAM Antibody: Anti-CD146/HEMCAM/METCAM8/MelCAM therapeutic antibody |
| INN Name | Imaprelimab |
| Target | MCAM |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2017 |
| Year Recommended | 2018 |
| Companies | Neotope Biosciences;Onclave Therapeutics;Prothena;Prothena Corporation |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Cancer;Inflammation;Psoriasis |
| Development Tech | na |
About target - MCAM
1. Protein Cell surface glycoprotein MUC18
2. Gene MCAM
3. Organism Homo sapiens (Human)
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
