Products
Refanezumab Biosimilar Monoclonal Antibody (MAG) for Research
Pre-Made Refanezumab biosimilar, Whole mAb, Anti-MAG Antibody: Anti-GMA/S-MAG/SIGLEC-4A/SIGLEC4A/SPG75 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Refanezumab (GSK249320) is a monoclonal antibody designed for the recovery of motor function after stroke.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-474-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Refanezumab biosimilar, Whole mAb, Anti-MAG Antibody: Anti-GMA/S-MAG/SIGLEC-4A/SIGLEC4A/SPG75 therapeutic antibody |
| INN Name | Refanezumab |
| Target | MAG |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2015 |
| Year Recommended | 2016 |
| Companies | GlaxoSmithKline |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | CNS trauma;Stroke |
| Development Tech | na |
About target - MAG
1. Protein Myelin-associated glycoprotein
2. Gene MAG
3. Organism Homo sapiens (Human)
Function
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity).
Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity).
Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity).
Inhibits axon outgrowth by binding to RTN4R (By similarity).
Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).
