Pre-made Timigutuzumab benchmark antibody ( Whole mAb, anti-ERBB2/HER2 therapeutic antibody, Anti-CD340/neu/MLN 19/NEU/NGL/TKR1/VSCN2 Antibody) for drug discovery and mechanism of action (MOA) research

Cat No.: GMP-Bios-ab-576

Pre-Made Timigutuzumab biosimilar, Whole mAb, Anti-ERBB2/HER2 Antibody: Anti-CD340/neu/MLN 19/NEU/NGL/TKR1/VSCN2 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

TrasGEX (timigutuzumab) is another antibody that has been glyco-optimized to enhance antibody-dependent cell-mediated cytotoxicity. ... HuA21 is a chimeric antibody targeted to subdomain I of the ErbB2 extracellular domain and it has been shown to markedly suppress the growth of trastuzumab-resistant cells.

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GMP-Bios-ab-576-1mg 1mg 3090 Inquiry Inquiry

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Description

Products Name (INN Index) Pre-Made Timigutuzumab biosimilar, Whole mAb, Anti-ERBB2/HER2 Antibody: Anti-CD340/neu/MLN 19/NEU/NGL/TKR1/VSCN2 therapeutic antibody
INN Name Timigutuzumab
TargetHER2
FormatWhole mAb
DerivationHumanized
Species ReactivityHuman
CH1 IsotypeIgG1
VD LCKappa
Highest_Clin_Trial (Jan '20)Phase-I
Est. StatusNFD
100% SI Structure1fvc:DC:BA/4hkz:BA/1n8z:BA/6bhz:HL:IM/6bi2:HL:IM/6bi0:HL:IM/5xhg:BA:DC/6mh2:AB:CD
99% SI Structure1fve:BA:DC/4x4x:AB:CD/6bgt:BA/7kbp:CC
95-98% SI Structure5tdo:DC/5tdn:BA:DC/5tdp:BA:DC/4x4y:CD:AB/1fvd:BA:DC/3be1:HL/3bdy:HL/5u6a:BA/5u3d:BA/5u5f:BA/6b9z:BA/5u5m:BA/6bah:BA/4ioi:BA/4hjg:BA/6bae:BA/6b9y:BA/6dn0:AB:CD/6my4:HL:AB/6mxs:HL:AB/6my5:AB:HL/6mxr:AB:HL
Year Proposed1997
Year Recommended1998
CompaniesRoche
Conditions ApprovedBreast cancer
Conditions Activena
Conditions Discontinuedna
Development Techna