Anti-SQLE monoclonal antibody

Pre-made anti-SQLE monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to SQLE/SQLE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0007-Ab-1/ GM-Tg-hg-IP0007-Ab-2Anti-Human SQLE monoclonal antibodyHuman
GM-Tg-rg-IP0007-Ab-1/ GM-Tg-rg-IP0007-Ab-2Anti-Rat SQLE monoclonal antibodyRat
GM-Tg-mg-IP0007-Ab-1/ GM-Tg-mg-IP0007-Ab-2Anti-Mouse SQLE monoclonal antibodyMouse
GM-Tg-cynog-IP0007-Ab-1/ GM-Tg-cynog-IP0007-Ab-2Anti-Cynomolgus/ Rhesus macaque SQLE monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0007-Ab-1/ GM-Tg-felg-IP0007-Ab-2Anti-Feline SQLE monoclonal antibodyFeline
GM-Tg-cang-IP0007-Ab-1/ GM-Tg-cang-IP0007-Ab-2Anti-Canine SQLE monoclonal antibodyCanine
GM-Tg-bovg-IP0007-Ab-1/ GM-Tg-bovg-IP0007-Ab-2Anti-Bovine SQLE monoclonal antibodyBovine
GM-Tg-equg-IP0007-Ab-1/ GM-Tg-equg-IP0007-Ab-2Anti-Equine SQLE monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0007-Ab-1/ GM-Tg-hg-IP0007-Ab-2; GM-Tg-rg-IP0007-Ab-1/ GM-Tg-rg-IP0007-Ab-2;
GM-Tg-mg-IP0007-Ab-1/ GM-Tg-mg-IP0007-Ab-2; GM-Tg-cynog-IP0007-Ab-1/ GM-Tg-cynog-IP0007-Ab-2;
GM-Tg-felg-IP0007-Ab-1/ GM-Tg-felg-IP0007-Ab-2; GM-Tg-cang-IP0007-Ab-1/ GM-Tg-cang-IP0007-Ab-2;
GM-Tg-bovg-IP0007-Ab-1/ GM-Tg-bovg-IP0007-Ab-2; GM-Tg-equg-IP0007-Ab-1/ GM-Tg-equg-IP0007-Ab-2
Products NameAnti-SQLE monoclonal antibody
Formatmab
Target NameSQLE
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-SQLE monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0007-Ag-1Recombinant multi-species ERG1/ SQLE protein
    ORF Viral VectorvGMLV000260human SQLE Lentivirus particle
    ORF Viral VectorpGMLV000260human SQLE Lentivirus plasmid
    ORF Viral VectorpGMLPm004071mouse Sqle Lentivirus plasmid
    ORF Viral VectorvGMLPm004071mouse Sqle Lentivirus particle


    Target information

    Target IDGM-IP0007
    Target NameSQLE
    Gene ID6713,20775,29230,706764,608021,101086537,526535,100067615
    Gene Symbol and SynonymsSQLE
    Uniprot AccessionQ14534,P52020
    Uniprot Entry NameERG1_HUMAN,ERG1_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000104549
    Target ClassificationN/A

    The target: SQLE, gene name: SQLE, also named as . Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.