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Anti-FANCA monoclonal antibody
Pre-made anti-FANCA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FANCA/FANCA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0029-Ab-1/ GM-Tg-hg-IP0029-Ab-2 | Anti-Human FANCA monoclonal antibody | Human |
| GM-Tg-rg-IP0029-Ab-1/ GM-Tg-rg-IP0029-Ab-2 | Anti-Rat FANCA monoclonal antibody | Rat |
| GM-Tg-mg-IP0029-Ab-1/ GM-Tg-mg-IP0029-Ab-2 | Anti-Mouse FANCA monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0029-Ab-1/ GM-Tg-cynog-IP0029-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FANCA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0029-Ab-1/ GM-Tg-felg-IP0029-Ab-2 | Anti-Feline FANCA monoclonal antibody | Feline |
| GM-Tg-cang-IP0029-Ab-1/ GM-Tg-cang-IP0029-Ab-2 | Anti-Canine FANCA monoclonal antibody | Canine |
| GM-Tg-bovg-IP0029-Ab-1/ GM-Tg-bovg-IP0029-Ab-2 | Anti-Bovine FANCA monoclonal antibody | Bovine |
| GM-Tg-equg-IP0029-Ab-1/ GM-Tg-equg-IP0029-Ab-2 | Anti-Equine FANCA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0029-Ab-1/ GM-Tg-hg-IP0029-Ab-2; GM-Tg-rg-IP0029-Ab-1/ GM-Tg-rg-IP0029-Ab-2; GM-Tg-mg-IP0029-Ab-1/ GM-Tg-mg-IP0029-Ab-2; GM-Tg-cynog-IP0029-Ab-1/ GM-Tg-cynog-IP0029-Ab-2; GM-Tg-felg-IP0029-Ab-1/ GM-Tg-felg-IP0029-Ab-2; GM-Tg-cang-IP0029-Ab-1/ GM-Tg-cang-IP0029-Ab-2; GM-Tg-bovg-IP0029-Ab-1/ GM-Tg-bovg-IP0029-Ab-2; GM-Tg-equg-IP0029-Ab-1/ GM-Tg-equg-IP0029-Ab-2 |
| Products Name | Anti-FANCA monoclonal antibody |
| Format | mab |
| Target Name | FANCA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FANCA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0029-Ag-1 | Recombinant multi-species FANCA/ FA/ FA-H protein |
Target information
| Target ID | GM-IP0029 |
| Target Name | FANCA |
| Gene ID | 2175,14087,361435,721746,608713,101081431,618375,100052495 |
| Gene Symbol and Synonyms | FA,FA-H,FA1,FAA,FACA,FAH,FANCA,FANCH,ZNF276 |
| Uniprot Accession | O15360 |
| Uniprot Entry Name | FANCA_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000187741 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FANCA, gene name: FANCA, also named as FA, FA-H, FA1, FAA, FACA, FAH, FANCH. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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