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Anti-REL1/ RLN1/ H1 functional antibody
Anti-REL1/ RLN1/ H1 functional antibody for cell culture, ELISA & in-vivo assay
Go to RLN1/RLN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1241-Ab-1/ GM-Tg-hg-SE1241-Ab-2 | Anti-Human RLN1 monoclonal antibody | Human |
| GM-Tg-rg-SE1241-Ab-1/ GM-Tg-rg-SE1241-Ab-2 | Anti-Rat RLN1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1241-Ab-1/ GM-Tg-mg-SE1241-Ab-2 | Anti-Mouse RLN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1241-Ab-1/ GM-Tg-cynog-SE1241-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RLN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1241-Ab-1/ GM-Tg-felg-SE1241-Ab-2 | Anti-Feline RLN1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1241-Ab-1/ GM-Tg-cang-SE1241-Ab-2 | Anti-Canine RLN1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1241-Ab-1/ GM-Tg-bovg-SE1241-Ab-2 | Anti-Bovine RLN1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1241-Ab-1/ GM-Tg-equg-SE1241-Ab-2 | Anti-Equine RLN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1241-Ab-1/ GM-Tg-hg-SE1241-Ab-2; GM-Tg-rg-SE1241-Ab-1/ GM-Tg-rg-SE1241-Ab-2; GM-Tg-mg-SE1241-Ab-1/ GM-Tg-mg-SE1241-Ab-2; GM-Tg-cynog-SE1241-Ab-1/ GM-Tg-cynog-SE1241-Ab-2; GM-Tg-felg-SE1241-Ab-1/ GM-Tg-felg-SE1241-Ab-2; GM-Tg-cang-SE1241-Ab-1/ GM-Tg-cang-SE1241-Ab-2; GM-Tg-bovg-SE1241-Ab-1/ GM-Tg-bovg-SE1241-Ab-2; GM-Tg-equg-SE1241-Ab-1/ GM-Tg-equg-SE1241-Ab-2 |
| Products Name | Anti-RLN1 monoclonal antibody |
| Format | mab |
| Target Name | RLN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RLN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1241-Ag-1 | Recombinant multi-species REL1/ RLN1/ H1 protein |
Target information
| Target ID | GM-SE1241 |
| Target Name | RLN1 |
| Gene ID | 6013 |
| Gene Symbol and Synonyms | bA12D24.3.1,bA12D24.3.2,H1,H1RLX,RLN1,RLXH1 |
| Uniprot Accession | P04808 |
| Uniprot Entry Name | REL1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000107018 |
| Target Classification | N/A |
The target: RLN1, gene name: RLN1, also named as H1, H1RLX, RLXH1, bA12D24.3.1, bA12D24.3.2. Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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