Anti-REL2/ RLN2/ H2 functional antibody

Anti-REL2/ RLN2/ H2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to RLN2/RLN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1242-Ab-1/ GM-Tg-hg-SE1242-Ab-2Anti-Human RLN2 monoclonal antibodyHuman
GM-Tg-rg-SE1242-Ab-1/ GM-Tg-rg-SE1242-Ab-2Anti-Rat RLN2 monoclonal antibodyRat
GM-Tg-mg-SE1242-Ab-1/ GM-Tg-mg-SE1242-Ab-2Anti-Mouse RLN2 monoclonal antibodyMouse
GM-Tg-cynog-SE1242-Ab-1/ GM-Tg-cynog-SE1242-Ab-2Anti-Cynomolgus/ Rhesus macaque RLN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1242-Ab-1/ GM-Tg-felg-SE1242-Ab-2Anti-Feline RLN2 monoclonal antibodyFeline
GM-Tg-cang-SE1242-Ab-1/ GM-Tg-cang-SE1242-Ab-2Anti-Canine RLN2 monoclonal antibodyCanine
GM-Tg-bovg-SE1242-Ab-1/ GM-Tg-bovg-SE1242-Ab-2Anti-Bovine RLN2 monoclonal antibodyBovine
GM-Tg-equg-SE1242-Ab-1/ GM-Tg-equg-SE1242-Ab-2Anti-Equine RLN2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1242-Ab-1/ GM-Tg-hg-SE1242-Ab-2; GM-Tg-rg-SE1242-Ab-1/ GM-Tg-rg-SE1242-Ab-2;
GM-Tg-mg-SE1242-Ab-1/ GM-Tg-mg-SE1242-Ab-2; GM-Tg-cynog-SE1242-Ab-1/ GM-Tg-cynog-SE1242-Ab-2;
GM-Tg-felg-SE1242-Ab-1/ GM-Tg-felg-SE1242-Ab-2; GM-Tg-cang-SE1242-Ab-1/ GM-Tg-cang-SE1242-Ab-2;
GM-Tg-bovg-SE1242-Ab-1/ GM-Tg-bovg-SE1242-Ab-2; GM-Tg-equg-SE1242-Ab-1/ GM-Tg-equg-SE1242-Ab-2
Products NameAnti-RLN2 monoclonal antibody
Formatmab
Target NameRLN2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RLN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1242-Ag-1Recombinant multi-species REL2/ RLN2/ H2 protein


    Target information

    Target IDGM-SE1242
    Target NameRLN2
    Gene ID6019
    Gene Symbol and SynonymsbA12D24.1.1,bA12D24.1.2,H2,H2-RLX,relaxin,RLN,RLN1,RLN2,RLXH2
    Uniprot AccessionP04090,Q9TRM8
    Uniprot Entry NameREL2_HUMAN,RELX_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000107014
    Target ClassificationN/A

    The target: RLN2, gene name: RLN2, also named as H2, H2-RLX, RLXH2, bA12D24.1.1, bA12D24.1.2. This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.