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Anti-UCMA/ C10orf49/ GRP functional antibody
Anti-UCMA/ C10orf49/ GRP functional antibody for cell culture, ELISA & in-vivo assay
Go to UCMA/UCMA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1355-Ab-1/ GM-Tg-hg-SE1355-Ab-2 | Anti-Human UCMA monoclonal antibody | Human |
| GM-Tg-rg-SE1355-Ab-1/ GM-Tg-rg-SE1355-Ab-2 | Anti-Rat UCMA monoclonal antibody | Rat |
| GM-Tg-mg-SE1355-Ab-1/ GM-Tg-mg-SE1355-Ab-2 | Anti-Mouse UCMA monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1355-Ab-1/ GM-Tg-cynog-SE1355-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UCMA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1355-Ab-1/ GM-Tg-felg-SE1355-Ab-2 | Anti-Feline UCMA monoclonal antibody | Feline |
| GM-Tg-cang-SE1355-Ab-1/ GM-Tg-cang-SE1355-Ab-2 | Anti-Canine UCMA monoclonal antibody | Canine |
| GM-Tg-bovg-SE1355-Ab-1/ GM-Tg-bovg-SE1355-Ab-2 | Anti-Bovine UCMA monoclonal antibody | Bovine |
| GM-Tg-equg-SE1355-Ab-1/ GM-Tg-equg-SE1355-Ab-2 | Anti-Equine UCMA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1355-Ab-1/ GM-Tg-hg-SE1355-Ab-2; GM-Tg-rg-SE1355-Ab-1/ GM-Tg-rg-SE1355-Ab-2; GM-Tg-mg-SE1355-Ab-1/ GM-Tg-mg-SE1355-Ab-2; GM-Tg-cynog-SE1355-Ab-1/ GM-Tg-cynog-SE1355-Ab-2; GM-Tg-felg-SE1355-Ab-1/ GM-Tg-felg-SE1355-Ab-2; GM-Tg-cang-SE1355-Ab-1/ GM-Tg-cang-SE1355-Ab-2; GM-Tg-bovg-SE1355-Ab-1/ GM-Tg-bovg-SE1355-Ab-2; GM-Tg-equg-SE1355-Ab-1/ GM-Tg-equg-SE1355-Ab-2 |
| Products Name | Anti-UCMA monoclonal antibody |
| Format | mab |
| Target Name | UCMA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-UCMA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1355-Ag-1 | Recombinant multi-species UCMA/ C10orf49/ GRP protein |
| ORF Viral Vector | pGMLPm000846 | mouse Ucma Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000846 | mouse Ucma Lentivirus particle |
Target information
| Target ID | GM-SE1355 |
| Target Name | UCMA |
| Gene ID | 221044,68527,291312,698795,478002,101097989,615924,100069244 |
| Gene Symbol and Synonyms | 1110017I16Rik,C10orf49,GRP,GRP/UCMA,RGD1308977,UCMA |
| Uniprot Accession | Q8WVF2,B9TQX4 |
| Uniprot Entry Name | UCMA_HUMAN,UCMA_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000165623 |
| Target Classification | N/A |
The target: UCMA, gene name: UCMA, also named as C10orf49, GRP, GRP/UCMA. This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
