Anti-GLIS3/ NDH/ ZNF515 functional antibody

Anti-GLIS3/ NDH/ ZNF515 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to GLIS3/GLIS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1453-Ab-1/ GM-Tg-hg-SE1453-Ab-2Anti-Human GLIS3 monoclonal antibodyHuman
GM-Tg-rg-SE1453-Ab-1/ GM-Tg-rg-SE1453-Ab-2Anti-Rat GLIS3 monoclonal antibodyRat
GM-Tg-mg-SE1453-Ab-1/ GM-Tg-mg-SE1453-Ab-2Anti-Mouse GLIS3 monoclonal antibodyMouse
GM-Tg-cynog-SE1453-Ab-1/ GM-Tg-cynog-SE1453-Ab-2Anti-Cynomolgus/ Rhesus macaque GLIS3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1453-Ab-1/ GM-Tg-felg-SE1453-Ab-2Anti-Feline GLIS3 monoclonal antibodyFeline
GM-Tg-cang-SE1453-Ab-1/ GM-Tg-cang-SE1453-Ab-2Anti-Canine GLIS3 monoclonal antibodyCanine
GM-Tg-bovg-SE1453-Ab-1/ GM-Tg-bovg-SE1453-Ab-2Anti-Bovine GLIS3 monoclonal antibodyBovine
GM-Tg-equg-SE1453-Ab-1/ GM-Tg-equg-SE1453-Ab-2Anti-Equine GLIS3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1453-Ab-1/ GM-Tg-hg-SE1453-Ab-2; GM-Tg-rg-SE1453-Ab-1/ GM-Tg-rg-SE1453-Ab-2;
GM-Tg-mg-SE1453-Ab-1/ GM-Tg-mg-SE1453-Ab-2; GM-Tg-cynog-SE1453-Ab-1/ GM-Tg-cynog-SE1453-Ab-2;
GM-Tg-felg-SE1453-Ab-1/ GM-Tg-felg-SE1453-Ab-2; GM-Tg-cang-SE1453-Ab-1/ GM-Tg-cang-SE1453-Ab-2;
GM-Tg-bovg-SE1453-Ab-1/ GM-Tg-bovg-SE1453-Ab-2; GM-Tg-equg-SE1453-Ab-1/ GM-Tg-equg-SE1453-Ab-2
Products NameAnti-GLIS3 monoclonal antibody
Formatmab
Target NameGLIS3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GLIS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1453-Ag-1Recombinant multi-species GLIS3/ NDH/ ZNF515 protein


    Target information

    Target IDGM-SE1453
    Target NameGLIS3
    Gene ID169792,226075,680671,694900,484179,101100094,524909,100051202
    Gene Symbol and Synonyms4833409N03Rik,E330013K21Rik,GLIS3,NDH,RGD1565505,ZNF515
    Uniprot AccessionQ8NEA6
    Uniprot Entry NameGLIS3_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000107249
    Target ClassificationN/A

    The target: GLIS3, gene name: GLIS3, also named as NDH, ZNF515. This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.