Anti-FHOD3/ FHOS2/ Formactin2 functional antibody for cell culture, ELISA & in-vivo assay| GMab

Pre-made anti-FHOD3 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-FHOD3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

The target: FHOD3, gene name: FHOD3, also named as FHOS2, Formactin2. The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015].

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Catalog No.	List Price (In USD)	Discount Price (In USD)	Qty (Quantity)	Sum (In USD)
GM-Tg-hg-SE1501-Ab-1-1mg	5150	3090
GM-Tg-hg-SE1501-Ab-1-10mg	Inquiry	Inquiry
GM-Tg-hg-SE1501-Ab-1-100mg	Inquiry	Inquiry
GM-Tg-hg-SE1501-Ab-2-1mg	5150	3090
GM-Tg-hg-SE1501-Ab-2-10mg	Inquiry	Inquiry
GM-Tg-hg-SE1501-Ab-2-100mg	Inquiry	Inquiry
GM-Tg-hg-SE1501-Ab-xmg	Inquiry	Inquiry
			Shipping Cost:	760.00
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Description

Catalog No.	GM-Tg-hg-SE1501-Ab-1, GM-Tg-hg-SE1501-Ab-2
Products Name	Anti-FHOD3 monoclonal antibody
Format	mab
Target Name	FHOD3
Gene ID	FHOD3
Gene Name	FHOD3
Gene Alias	FHOS2, Formactin2
Protein Sub-location	Secreted Protein/Potential Cytokines
Category of antibody	FACS/Biofunctional Antibody
Derivation (species)	Mouse
Species Reactivity	Human(H)
CH1+2+3 Isotype (Receptor identification)	IgG
Type of Light Chain (VD-LC)	N/A
Expression platform	Mammalian Expression
Bioactivity validation	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Tag	Fc
Products description	Pre-made anti-FHOD3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity	Purity: ≥95% (SDS-PAGE)
Application	Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.