Anti-RM24/ MRPL24/ L24mt functional antibody

Anti-RM24/ MRPL24/ L24mt functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MRPL24/MRPL24 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1522-Ab-1/ GM-Tg-hg-SE1522-Ab-2Anti-Human MRPL24 monoclonal antibodyHuman
GM-Tg-rg-SE1522-Ab-1/ GM-Tg-rg-SE1522-Ab-2Anti-Rat MRPL24 monoclonal antibodyRat
GM-Tg-mg-SE1522-Ab-1/ GM-Tg-mg-SE1522-Ab-2Anti-Mouse MRPL24 monoclonal antibodyMouse
GM-Tg-cynog-SE1522-Ab-1/ GM-Tg-cynog-SE1522-Ab-2Anti-Cynomolgus/ Rhesus macaque MRPL24 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1522-Ab-1/ GM-Tg-felg-SE1522-Ab-2Anti-Feline MRPL24 monoclonal antibodyFeline
GM-Tg-cang-SE1522-Ab-1/ GM-Tg-cang-SE1522-Ab-2Anti-Canine MRPL24 monoclonal antibodyCanine
GM-Tg-bovg-SE1522-Ab-1/ GM-Tg-bovg-SE1522-Ab-2Anti-Bovine MRPL24 monoclonal antibodyBovine
GM-Tg-equg-SE1522-Ab-1/ GM-Tg-equg-SE1522-Ab-2Anti-Equine MRPL24 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1522-Ab-1/ GM-Tg-hg-SE1522-Ab-2; GM-Tg-rg-SE1522-Ab-1/ GM-Tg-rg-SE1522-Ab-2;
GM-Tg-mg-SE1522-Ab-1/ GM-Tg-mg-SE1522-Ab-2; GM-Tg-cynog-SE1522-Ab-1/ GM-Tg-cynog-SE1522-Ab-2;
GM-Tg-felg-SE1522-Ab-1/ GM-Tg-felg-SE1522-Ab-2; GM-Tg-cang-SE1522-Ab-1/ GM-Tg-cang-SE1522-Ab-2;
GM-Tg-bovg-SE1522-Ab-1/ GM-Tg-bovg-SE1522-Ab-2; GM-Tg-equg-SE1522-Ab-1/ GM-Tg-equg-SE1522-Ab-2
Products NameAnti-MRPL24 monoclonal antibody
Formatmab
Target NameMRPL24
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MRPL24 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1522-Ag-1Recombinant multi-species RM24/ MRPL24/ L24mt protein


    Target information

    Target IDGM-SE1522
    Target NameMRPL24
    Gene ID79590,67707,295224,106992264,490407,101082038,532203,100058163
    Gene Symbol and Synonyms2010005E08Rik,2810470K06Rik,6720473G22Rik,L24mt,MRP-L18,MRP-L24,MRPL24
    Uniprot AccessionQ96A35,Q66H47,Q3SYS0
    Uniprot Entry NameRM24_HUMAN,RM24_RAT,RM24_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000143314
    Target ClassificationN/A

    The target: MRPL24, gene name: MRPL24, also named as L24mt, MRP-L18, MRP-L24. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.