Anti-KDM6A/ KABUK2/ UTX functional antibody

Anti-KDM6A/ KABUK2/ UTX functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to KDM6A/KDM6A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1529-Ab-1/ GM-Tg-hg-SE1529-Ab-2Anti-Human KDM6A monoclonal antibodyHuman
GM-Tg-rg-SE1529-Ab-1/ GM-Tg-rg-SE1529-Ab-2Anti-Rat KDM6A monoclonal antibodyRat
GM-Tg-mg-SE1529-Ab-1/ GM-Tg-mg-SE1529-Ab-2Anti-Mouse KDM6A monoclonal antibodyMouse
GM-Tg-cynog-SE1529-Ab-1/ GM-Tg-cynog-SE1529-Ab-2Anti-Cynomolgus/ Rhesus macaque KDM6A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1529-Ab-1/ GM-Tg-felg-SE1529-Ab-2Anti-Feline KDM6A monoclonal antibodyFeline
GM-Tg-cang-SE1529-Ab-1/ GM-Tg-cang-SE1529-Ab-2Anti-Canine KDM6A monoclonal antibodyCanine
GM-Tg-bovg-SE1529-Ab-1/ GM-Tg-bovg-SE1529-Ab-2Anti-Bovine KDM6A monoclonal antibodyBovine
GM-Tg-equg-SE1529-Ab-1/ GM-Tg-equg-SE1529-Ab-2Anti-Equine KDM6A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1529-Ab-1/ GM-Tg-hg-SE1529-Ab-2; GM-Tg-rg-SE1529-Ab-1/ GM-Tg-rg-SE1529-Ab-2;
GM-Tg-mg-SE1529-Ab-1/ GM-Tg-mg-SE1529-Ab-2; GM-Tg-cynog-SE1529-Ab-1/ GM-Tg-cynog-SE1529-Ab-2;
GM-Tg-felg-SE1529-Ab-1/ GM-Tg-felg-SE1529-Ab-2; GM-Tg-cang-SE1529-Ab-1/ GM-Tg-cang-SE1529-Ab-2;
GM-Tg-bovg-SE1529-Ab-1/ GM-Tg-bovg-SE1529-Ab-2; GM-Tg-equg-SE1529-Ab-1/ GM-Tg-equg-SE1529-Ab-2
Products NameAnti-KDM6A monoclonal antibody
Formatmab
Target NameKDM6A
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KDM6A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1529-Ag-1Recombinant multi-species KDM6A/ KABUK2/ UTX protein


    Target information

    Target IDGM-SE1529
    Target NameKDM6A
    Gene ID7403,22289,103689969,100427119,491845,101088307,280952,100059800
    Gene Symbol and SynonymsbA386N14.2,KABUK2,KDM6A,UTX
    Uniprot AccessionO15550
    Uniprot Entry NameKDM6A_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000147050
    Target ClassificationN/A

    The target: KDM6A, gene name: KDM6A, also named as KABUK2, UTX, bA386N14.2. This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.