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Anti-ABCA1/ ABC-1/ ABC1 monoclonal antibody
Anti-ABCA1/ ABC-1/ ABC1 antibody for FACS & in-vivo assay
Go to ABCA1/ABCA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00494-Ab-1/ GM-Tg-hg-T00494-Ab-2 | Anti-Human ABCA1 monoclonal antibody | Human |
| GM-Tg-rg-T00494-Ab-1/ GM-Tg-rg-T00494-Ab-2 | Anti-Rat ABCA1 monoclonal antibody | Rat |
| GM-Tg-mg-T00494-Ab-1/ GM-Tg-mg-T00494-Ab-2 | Anti-Mouse ABCA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T00494-Ab-1/ GM-Tg-cynog-T00494-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ABCA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00494-Ab-1/ GM-Tg-felg-T00494-Ab-2 | Anti-Feline ABCA1 monoclonal antibody | Feline |
| GM-Tg-cang-T00494-Ab-1/ GM-Tg-cang-T00494-Ab-2 | Anti-Canine ABCA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T00494-Ab-1/ GM-Tg-bovg-T00494-Ab-2 | Anti-Bovine ABCA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T00494-Ab-1/ GM-Tg-equg-T00494-Ab-2 | Anti-Equine ABCA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00494-Ab-1/ GM-Tg-hg-T00494-Ab-2; GM-Tg-rg-T00494-Ab-1/ GM-Tg-rg-T00494-Ab-2; GM-Tg-mg-T00494-Ab-1/ GM-Tg-mg-T00494-Ab-2; GM-Tg-cynog-T00494-Ab-1/ GM-Tg-cynog-T00494-Ab-2; GM-Tg-felg-T00494-Ab-1/ GM-Tg-felg-T00494-Ab-2; GM-Tg-cang-T00494-Ab-1/ GM-Tg-cang-T00494-Ab-2; GM-Tg-bovg-T00494-Ab-1/ GM-Tg-bovg-T00494-Ab-2; GM-Tg-equg-T00494-Ab-1/ GM-Tg-equg-T00494-Ab-2 |
| Products Name | Anti-ABCA1 monoclonal antibody |
| Format | mab |
| Target Name | ABCA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ABCA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ABCA1/ ABC-1/ ABC1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T00494 |
| Target Name | ABCA1 |
| Gene ID | 19,11303,313210,716146,481651,101083885,535379,100054241 |
| Gene Symbol and Synonyms | ABC-1,ABC1,ABCA1,CERP,HDLCQTL13,HDLDT1,HPALP1,TGD |
| Uniprot Accession | O95477 |
| Uniprot Entry Name | ABCA1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000165029 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ABCA1, gene name: ABCA1, also named as ABC-1, ABC1, CERP, HDLDT1, TGD. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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