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Anti-PAWR/ PAR4/ Par-4 monoclonal antibody
Anti-PAWR/ PAR4/ Par-4 antibody for FACS & in-vivo assay
Go to PAWR/PAWR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00496-Ab-1/ GM-Tg-hg-T00496-Ab-2 | Anti-Human PAWR monoclonal antibody | Human |
| GM-Tg-rg-T00496-Ab-1/ GM-Tg-rg-T00496-Ab-2 | Anti-Rat PAWR monoclonal antibody | Rat |
| GM-Tg-mg-T00496-Ab-1/ GM-Tg-mg-T00496-Ab-2 | Anti-Mouse PAWR monoclonal antibody | Mouse |
| GM-Tg-cynog-T00496-Ab-1/ GM-Tg-cynog-T00496-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PAWR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00496-Ab-1/ GM-Tg-felg-T00496-Ab-2 | Anti-Feline PAWR monoclonal antibody | Feline |
| GM-Tg-cang-T00496-Ab-1/ GM-Tg-cang-T00496-Ab-2 | Anti-Canine PAWR monoclonal antibody | Canine |
| GM-Tg-bovg-T00496-Ab-1/ GM-Tg-bovg-T00496-Ab-2 | Anti-Bovine PAWR monoclonal antibody | Bovine |
| GM-Tg-equg-T00496-Ab-1/ GM-Tg-equg-T00496-Ab-2 | Anti-Equine PAWR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00496-Ab-1/ GM-Tg-hg-T00496-Ab-2; GM-Tg-rg-T00496-Ab-1/ GM-Tg-rg-T00496-Ab-2; GM-Tg-mg-T00496-Ab-1/ GM-Tg-mg-T00496-Ab-2; GM-Tg-cynog-T00496-Ab-1/ GM-Tg-cynog-T00496-Ab-2; GM-Tg-felg-T00496-Ab-1/ GM-Tg-felg-T00496-Ab-2; GM-Tg-cang-T00496-Ab-1/ GM-Tg-cang-T00496-Ab-2; GM-Tg-bovg-T00496-Ab-1/ GM-Tg-bovg-T00496-Ab-2; GM-Tg-equg-T00496-Ab-1/ GM-Tg-equg-T00496-Ab-2 |
| Products Name | Anti-PAWR monoclonal antibody |
| Format | mab |
| Target Name | PAWR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PAWR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PAWR/ PAR4/ Par-4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000142 | human PAWR Adenovirus particle |
| ORF Viral Vector | pGMAD000440 | human PAWR Adenovirus plasmid |
| ORF Viral Vector | vGMAD000440 | human PAWR Adenovirus particle |
| ORF Viral Vector | pGMAD000142 | human PAWR Adenovirus plasmid |
| ORF Viral Vector | pGMLPm005289 | mouse Pawr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005289 | mouse Pawr Lentivirus particle |
Target information
| Target ID | GM-T00496 |
| Target Name | PAWR |
| Gene ID | 5074,114774,64513,695617,611487,101090029,532789,100060291 |
| Gene Symbol and Synonyms | 2310001G03Rik,Par-4,PAR4,PAWR |
| Uniprot Accession | Q96IZ0,Q62627 |
| Uniprot Entry Name | PAWR_HUMAN,PAWR_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000177425 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PAWR, gene name: PAWR, also named as PAR4, Par-4. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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