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Anti-DRD3/ D3R/ D3DR monoclonal antibody
Anti-DRD3/ D3R/ D3DR antibody for FACS & in-vivo assay
Go to D3R/DRD3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02551-Ab-1/ GM-Tg-hg-T02551-Ab-2 | Anti-Human D3R/DRD3 monoclonal antibody | Human |
| GM-Tg-rg-T02551-Ab-1/ GM-Tg-rg-T02551-Ab-2 | Anti-Rat D3R/DRD3 monoclonal antibody | Rat |
| GM-Tg-mg-T02551-Ab-1/ GM-Tg-mg-T02551-Ab-2 | Anti-Mouse D3R/DRD3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T02551-Ab-1/ GM-Tg-cynog-T02551-Ab-2 | Anti-Cynomolgus/ Rhesus macaque D3R/DRD3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02551-Ab-1/ GM-Tg-felg-T02551-Ab-2 | Anti-Feline D3R/DRD3 monoclonal antibody | Feline |
| GM-Tg-cang-T02551-Ab-1/ GM-Tg-cang-T02551-Ab-2 | Anti-Canine D3R/DRD3 monoclonal antibody | Canine |
| GM-Tg-bovg-T02551-Ab-1/ GM-Tg-bovg-T02551-Ab-2 | Anti-Bovine D3R/DRD3 monoclonal antibody | Bovine |
| GM-Tg-equg-T02551-Ab-1/ GM-Tg-equg-T02551-Ab-2 | Anti-Equine D3R/DRD3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02551-Ab-1/ GM-Tg-hg-T02551-Ab-2; GM-Tg-rg-T02551-Ab-1/ GM-Tg-rg-T02551-Ab-2; GM-Tg-mg-T02551-Ab-1/ GM-Tg-mg-T02551-Ab-2; GM-Tg-cynog-T02551-Ab-1/ GM-Tg-cynog-T02551-Ab-2; GM-Tg-felg-T02551-Ab-1/ GM-Tg-felg-T02551-Ab-2; GM-Tg-cang-T02551-Ab-1/ GM-Tg-cang-T02551-Ab-2; GM-Tg-bovg-T02551-Ab-1/ GM-Tg-bovg-T02551-Ab-2; GM-Tg-equg-T02551-Ab-1/ GM-Tg-equg-T02551-Ab-2 |
| Products Name | Anti-D3R/DRD3 monoclonal antibody |
| Format | mab |
| Target Name | D3R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-D3R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DRD3/ D3R/ D3DR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003645 | human DRD3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003645 | human DRD3 Lentivirus particle |
| ORF Viral Vector | pGMLPm004847 | mouse Drd3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004847 | mouse Drd3 Lentivirus particle |
Target information
| Target ID | GM-T02551 |
| Target Name | D3R |
| Gene ID | 1814,13490,29238,100425047,487984,101092878,537043,100061160 |
| Gene Symbol and Synonyms | D3DR,D3R,DRD3,E™1,FET1 |
| Uniprot Accession | P35462,P19020 |
| Uniprot Entry Name | DRD3_HUMAN,DRD3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000151577 |
| Target Classification | N/A |
The target: D3R, gene name: DRD3, also named as D3DR, E™1, FET1. This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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