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Anti-NTRK1/ TrkA/ MTC monoclonal antibody
Anti-NTRK1/ TrkA/ MTC antibody for FACS & in-vivo assay
Go to TrkA/NTRK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T07173-Ab-1/ GM-Tg-hg-T07173-Ab-2 | Anti-Human TrkA/NTRK1 monoclonal antibody | Human |
| GM-Tg-rg-T07173-Ab-1/ GM-Tg-rg-T07173-Ab-2 | Anti-Rat TrkA/NTRK1 monoclonal antibody | Rat |
| GM-Tg-mg-T07173-Ab-1/ GM-Tg-mg-T07173-Ab-2 | Anti-Mouse TrkA/NTRK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T07173-Ab-1/ GM-Tg-cynog-T07173-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TrkA/NTRK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T07173-Ab-1/ GM-Tg-felg-T07173-Ab-2 | Anti-Feline TrkA/NTRK1 monoclonal antibody | Feline |
| GM-Tg-cang-T07173-Ab-1/ GM-Tg-cang-T07173-Ab-2 | Anti-Canine TrkA/NTRK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T07173-Ab-1/ GM-Tg-bovg-T07173-Ab-2 | Anti-Bovine TrkA/NTRK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T07173-Ab-1/ GM-Tg-equg-T07173-Ab-2 | Anti-Equine TrkA/NTRK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T07173-Ab-1/ GM-Tg-hg-T07173-Ab-2; GM-Tg-rg-T07173-Ab-1/ GM-Tg-rg-T07173-Ab-2; GM-Tg-mg-T07173-Ab-1/ GM-Tg-mg-T07173-Ab-2; GM-Tg-cynog-T07173-Ab-1/ GM-Tg-cynog-T07173-Ab-2; GM-Tg-felg-T07173-Ab-1/ GM-Tg-felg-T07173-Ab-2; GM-Tg-cang-T07173-Ab-1/ GM-Tg-cang-T07173-Ab-2; GM-Tg-bovg-T07173-Ab-1/ GM-Tg-bovg-T07173-Ab-2; GM-Tg-equg-T07173-Ab-1/ GM-Tg-equg-T07173-Ab-2 |
| Products Name | Anti-TrkA/NTRK1 monoclonal antibody |
| Format | mab |
| Target Name | TrkA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TrkA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NTRK1/ TrkA/ MTC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000500 | human NTRK1 Lentivirus particle |
| ORF Viral Vector | vGMLV000283 | human NTRK1 Lentivirus particle |
| ORF Viral Vector | pGMLV000501 | human NTRK1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000500 | human NTRK1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000501 | human NTRK1 Lentivirus particle |
| ORF Viral Vector | pGMLV000283 | human NTRK1 Lentivirus plasmid |
Target information
| Target ID | GM-T07173 |
| Target Name | TrkA |
| Gene ID | 4914,18211,59109,719670,490404,101081603,353111,100064594 |
| Gene Symbol and Synonyms | MTC,NTRK1,p140-TrkA,Tkr,TRK,Trk-A,TRK1,TRKA |
| Uniprot Accession | P04629,P35739 |
| Uniprot Entry Name | NTRK1_HUMAN,NTRK1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000198400 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: TrkA, gene name: NTRK1, also named as MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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