Anti-NTRK1/ TrkA/ MTC monoclonal antibody

Anti-NTRK1/ TrkA/ MTC antibody for FACS & in-vivo assay

Target products collectionGo to TrkA/NTRK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T07173-Ab-1/ GM-Tg-hg-T07173-Ab-2Anti-Human TrkA/NTRK1 monoclonal antibodyHuman
GM-Tg-rg-T07173-Ab-1/ GM-Tg-rg-T07173-Ab-2Anti-Rat TrkA/NTRK1 monoclonal antibodyRat
GM-Tg-mg-T07173-Ab-1/ GM-Tg-mg-T07173-Ab-2Anti-Mouse TrkA/NTRK1 monoclonal antibodyMouse
GM-Tg-cynog-T07173-Ab-1/ GM-Tg-cynog-T07173-Ab-2Anti-Cynomolgus/ Rhesus macaque TrkA/NTRK1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T07173-Ab-1/ GM-Tg-felg-T07173-Ab-2Anti-Feline TrkA/NTRK1 monoclonal antibodyFeline
GM-Tg-cang-T07173-Ab-1/ GM-Tg-cang-T07173-Ab-2Anti-Canine TrkA/NTRK1 monoclonal antibodyCanine
GM-Tg-bovg-T07173-Ab-1/ GM-Tg-bovg-T07173-Ab-2Anti-Bovine TrkA/NTRK1 monoclonal antibodyBovine
GM-Tg-equg-T07173-Ab-1/ GM-Tg-equg-T07173-Ab-2Anti-Equine TrkA/NTRK1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T07173-Ab-1/ GM-Tg-hg-T07173-Ab-2; GM-Tg-rg-T07173-Ab-1/ GM-Tg-rg-T07173-Ab-2;
GM-Tg-mg-T07173-Ab-1/ GM-Tg-mg-T07173-Ab-2; GM-Tg-cynog-T07173-Ab-1/ GM-Tg-cynog-T07173-Ab-2;
GM-Tg-felg-T07173-Ab-1/ GM-Tg-felg-T07173-Ab-2; GM-Tg-cang-T07173-Ab-1/ GM-Tg-cang-T07173-Ab-2;
GM-Tg-bovg-T07173-Ab-1/ GM-Tg-bovg-T07173-Ab-2; GM-Tg-equg-T07173-Ab-1/ GM-Tg-equg-T07173-Ab-2
Products NameAnti-TrkA/NTRK1 monoclonal antibody
Formatmab
Target NameTrkA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TrkA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NTRK1/ TrkA/ MTC VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000500human NTRK1 Lentivirus particle
    ORF Viral VectorvGMLV000283human NTRK1 Lentivirus particle
    ORF Viral VectorpGMLV000501human NTRK1 Lentivirus plasmid
    ORF Viral VectorpGMLV000500human NTRK1 Lentivirus plasmid
    ORF Viral VectorvGMLV000501human NTRK1 Lentivirus particle
    ORF Viral VectorpGMLV000283human NTRK1 Lentivirus plasmid


    Target information

    Target IDGM-T07173
    Target NameTrkA
    Gene ID4914,18211,59109,719670,490404,101081603,353111,100064594
    Gene Symbol and SynonymsMTC,NTRK1,p140-TrkA,Tkr,TRK,Trk-A,TRK1,TRKA
    Uniprot AccessionP04629,P35739
    Uniprot Entry NameNTRK1_HUMAN,NTRK1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000198400
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: TrkA, gene name: NTRK1, also named as MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.