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Anti-LRRK2 monoclonal antibody
Pre-made anti-LRRK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LRRK2/LRRK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T08123-Ab-1/ GM-Tg-hg-T08123-Ab-2 | Anti-Human LRRK2 monoclonal antibody | Human |
| GM-Tg-rg-T08123-Ab-1/ GM-Tg-rg-T08123-Ab-2 | Anti-Rat LRRK2 monoclonal antibody | Rat |
| GM-Tg-mg-T08123-Ab-1/ GM-Tg-mg-T08123-Ab-2 | Anti-Mouse LRRK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T08123-Ab-1/ GM-Tg-cynog-T08123-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRRK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T08123-Ab-1/ GM-Tg-felg-T08123-Ab-2 | Anti-Feline LRRK2 monoclonal antibody | Feline |
| GM-Tg-cang-T08123-Ab-1/ GM-Tg-cang-T08123-Ab-2 | Anti-Canine LRRK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T08123-Ab-1/ GM-Tg-bovg-T08123-Ab-2 | Anti-Bovine LRRK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T08123-Ab-1/ GM-Tg-equg-T08123-Ab-2 | Anti-Equine LRRK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T08123-Ab-1/ GM-Tg-hg-T08123-Ab-2; GM-Tg-rg-T08123-Ab-1/ GM-Tg-rg-T08123-Ab-2; GM-Tg-mg-T08123-Ab-1/ GM-Tg-mg-T08123-Ab-2; GM-Tg-cynog-T08123-Ab-1/ GM-Tg-cynog-T08123-Ab-2; GM-Tg-felg-T08123-Ab-1/ GM-Tg-felg-T08123-Ab-2; GM-Tg-cang-T08123-Ab-1/ GM-Tg-cang-T08123-Ab-2; GM-Tg-bovg-T08123-Ab-1/ GM-Tg-bovg-T08123-Ab-2; GM-Tg-equg-T08123-Ab-1/ GM-Tg-equg-T08123-Ab-2 |
| Products Name | Anti-LRRK2 monoclonal antibody |
| Format | mab |
| Target Name | LRRK2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LRRK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T08123-Ag-1 | Recombinant multi-species LRRK2/ AURA17/ DARDARIN protein |
Target information
| Target ID | GM-T08123 |
| Target Name | LRRK2 |
| Gene ID | 120892,66725,300160,697930,486608,101096157,535652,100052935 |
| Gene Symbol and Synonyms | 4921513O20Rik,9330188B09Rik,AURA17,cI-46,D630001M17Rik,DARDARIN,Gm927,LRRK2,PARK8,RIPK7,ROCO2 |
| Uniprot Accession | Q5S007 |
| Uniprot Entry Name | LRRK2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Parkinson's disease |
| Gene Ensembl | ENSG00000188906 |
| Target Classification | Kinase |
The target: LRRK2, gene name: LRRK2, also named as AURA17, DARDARIN, PARK8, RIPK7, ROCO2. This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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