Anti-CCR5/ CC-CKR-5/ CCCKR5 monoclonal antibody

Anti-CCR5/ CC-CKR-5/ CCCKR5 antibody for FACS & in-vivo assay

Target products collectionGo to CCR5/CCR5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T09960-Ab-1/ GM-Tg-hg-T09960-Ab-2Anti-Human CCR5 monoclonal antibodyHuman
GM-Tg-rg-T09960-Ab-1/ GM-Tg-rg-T09960-Ab-2Anti-Rat CCR5 monoclonal antibodyRat
GM-Tg-mg-T09960-Ab-1/ GM-Tg-mg-T09960-Ab-2Anti-Mouse CCR5 monoclonal antibodyMouse
GM-Tg-cynog-T09960-Ab-1/ GM-Tg-cynog-T09960-Ab-2Anti-Cynomolgus/ Rhesus macaque CCR5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T09960-Ab-1/ GM-Tg-felg-T09960-Ab-2Anti-Feline CCR5 monoclonal antibodyFeline
GM-Tg-cang-T09960-Ab-1/ GM-Tg-cang-T09960-Ab-2Anti-Canine CCR5 monoclonal antibodyCanine
GM-Tg-bovg-T09960-Ab-1/ GM-Tg-bovg-T09960-Ab-2Anti-Bovine CCR5 monoclonal antibodyBovine
GM-Tg-equg-T09960-Ab-1/ GM-Tg-equg-T09960-Ab-2Anti-Equine CCR5 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T09960-Ab-1/ GM-Tg-hg-T09960-Ab-2; GM-Tg-rg-T09960-Ab-1/ GM-Tg-rg-T09960-Ab-2;
GM-Tg-mg-T09960-Ab-1/ GM-Tg-mg-T09960-Ab-2; GM-Tg-cynog-T09960-Ab-1/ GM-Tg-cynog-T09960-Ab-2;
GM-Tg-felg-T09960-Ab-1/ GM-Tg-felg-T09960-Ab-2; GM-Tg-cang-T09960-Ab-1/ GM-Tg-cang-T09960-Ab-2;
GM-Tg-bovg-T09960-Ab-1/ GM-Tg-bovg-T09960-Ab-2; GM-Tg-equg-T09960-Ab-1/ GM-Tg-equg-T09960-Ab-2
Products NameAnti-CCR5 monoclonal antibody
Formatmab
Target NameCCR5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-304Pre-Made Leronlimab biosimilar, Whole mAb, Anti-CCR5 Antibody: Anti-CKR5/CCR-5/CD195/CKR-5/CCCKR5/CMKBR5/IDDM22/CC-CKR-5 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CCR5/ CC-CKR-5/ CCCKR5 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T09960-Ag-1chemokine (C-C motif) receptor 5 (CCR5) protein
    ORF Viral VectorpGMLP003863human CCR5 Lentivirus plasmid
    ORF Viral VectorvGMLP003863human CCR5 Lentivirus particle


    Target information

    Target IDGM-T09960
    Target NameCCR5
    Gene ID1234,735311,100048935
    Gene Symbol and SynonymsCC-CKR-5,CCCKR5,CCR-5,CCR5,CD195,CKR-5,CKR5,CMKBR5,IDDM22
    Uniprot AccessionP51681,P61813
    Uniprot Entry NameCCR5_HUMAN,CCR5_MACMU
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseHIV infection
    Gene EnsemblENSG00000160791
    Target ClassificationCheckpoint-Immuno Oncology, GPCR

    The target: CCR5, gene name: CCR5, also named as CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.