Anti-PTPRS/ R-PTP-sigma/ PTPSIGMA monoclonal antibody
Anti-PTPRS/ R-PTP-sigma/ PTPSIGMA antibody for FACS & in-vivo assay
Go to R-PTP-sigma/PTPRS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T10147-Ab-1/ GM-Tg-hg-T10147-Ab-2 | Anti-Human R-PTP-sigma/PTPRS monoclonal antibody | Human |
GM-Tg-rg-T10147-Ab-1/ GM-Tg-rg-T10147-Ab-2 | Anti-Rat R-PTP-sigma/PTPRS monoclonal antibody | Rat |
GM-Tg-mg-T10147-Ab-1/ GM-Tg-mg-T10147-Ab-2 | Anti-Mouse R-PTP-sigma/PTPRS monoclonal antibody | Mouse |
GM-Tg-cynog-T10147-Ab-1/ GM-Tg-cynog-T10147-Ab-2 | Anti-Cynomolgus/ Rhesus macaque R-PTP-sigma/PTPRS monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T10147-Ab-1/ GM-Tg-felg-T10147-Ab-2 | Anti-Feline R-PTP-sigma/PTPRS monoclonal antibody | Feline |
GM-Tg-cang-T10147-Ab-1/ GM-Tg-cang-T10147-Ab-2 | Anti-Canine R-PTP-sigma/PTPRS monoclonal antibody | Canine |
GM-Tg-bovg-T10147-Ab-1/ GM-Tg-bovg-T10147-Ab-2 | Anti-Bovine R-PTP-sigma/PTPRS monoclonal antibody | Bovine |
GM-Tg-equg-T10147-Ab-1/ GM-Tg-equg-T10147-Ab-2 | Anti-Equine R-PTP-sigma/PTPRS monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T10147-Ab-1/ GM-Tg-hg-T10147-Ab-2; GM-Tg-rg-T10147-Ab-1/ GM-Tg-rg-T10147-Ab-2; GM-Tg-mg-T10147-Ab-1/ GM-Tg-mg-T10147-Ab-2; GM-Tg-cynog-T10147-Ab-1/ GM-Tg-cynog-T10147-Ab-2; GM-Tg-felg-T10147-Ab-1/ GM-Tg-felg-T10147-Ab-2; GM-Tg-cang-T10147-Ab-1/ GM-Tg-cang-T10147-Ab-2; GM-Tg-bovg-T10147-Ab-1/ GM-Tg-bovg-T10147-Ab-2; GM-Tg-equg-T10147-Ab-1/ GM-Tg-equg-T10147-Ab-2 |
Products Name | Anti-R-PTP-sigma/PTPRS monoclonal antibody |
Format | mab |
Target Name | R-PTP-sigma |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-R-PTP-sigma benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species PTPRS/ R-PTP-sigma/ PTPSIGMA VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T10147 |
Target Name | R-PTP-sigma |
Gene ID | 5802,19280,25529,574274,485030,101083913,537480,102149682 |
Gene Symbol and Synonyms | Larptp2,PTP,PTP-NU3,PTPNU-3,Ptprd,PTPRS,PTPSIGMA,Ptpsigma.,Ptpt9,R-PTP-S,R-PTP-sigma,Rptpd,RPTPsigma |
Uniprot Accession | Q13332,Q64605 |
Uniprot Entry Name | PTPRS_HUMAN,PTPRS_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Ovary Cancer |
Gene Ensembl | ENSG00000105426 |
Target Classification | N/A |
The target: R-PTP-sigma, gene name: PTPRS, also named as PTPSIGMA, R-PTP-S, R-PTP-sigma. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.