Anti-PTPRS/ R-PTP-sigma/ PTPSIGMA monoclonal antibody

Anti-PTPRS/ R-PTP-sigma/ PTPSIGMA antibody for FACS & in-vivo assay

Target products collectionGo to R-PTP-sigma/PTPRS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T10147-Ab-1/ GM-Tg-hg-T10147-Ab-2Anti-Human R-PTP-sigma/PTPRS monoclonal antibodyHuman
GM-Tg-rg-T10147-Ab-1/ GM-Tg-rg-T10147-Ab-2Anti-Rat R-PTP-sigma/PTPRS monoclonal antibodyRat
GM-Tg-mg-T10147-Ab-1/ GM-Tg-mg-T10147-Ab-2Anti-Mouse R-PTP-sigma/PTPRS monoclonal antibodyMouse
GM-Tg-cynog-T10147-Ab-1/ GM-Tg-cynog-T10147-Ab-2Anti-Cynomolgus/ Rhesus macaque R-PTP-sigma/PTPRS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T10147-Ab-1/ GM-Tg-felg-T10147-Ab-2Anti-Feline R-PTP-sigma/PTPRS monoclonal antibodyFeline
GM-Tg-cang-T10147-Ab-1/ GM-Tg-cang-T10147-Ab-2Anti-Canine R-PTP-sigma/PTPRS monoclonal antibodyCanine
GM-Tg-bovg-T10147-Ab-1/ GM-Tg-bovg-T10147-Ab-2Anti-Bovine R-PTP-sigma/PTPRS monoclonal antibodyBovine
GM-Tg-equg-T10147-Ab-1/ GM-Tg-equg-T10147-Ab-2Anti-Equine R-PTP-sigma/PTPRS monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T10147-Ab-1/ GM-Tg-hg-T10147-Ab-2; GM-Tg-rg-T10147-Ab-1/ GM-Tg-rg-T10147-Ab-2;
GM-Tg-mg-T10147-Ab-1/ GM-Tg-mg-T10147-Ab-2; GM-Tg-cynog-T10147-Ab-1/ GM-Tg-cynog-T10147-Ab-2;
GM-Tg-felg-T10147-Ab-1/ GM-Tg-felg-T10147-Ab-2; GM-Tg-cang-T10147-Ab-1/ GM-Tg-cang-T10147-Ab-2;
GM-Tg-bovg-T10147-Ab-1/ GM-Tg-bovg-T10147-Ab-2; GM-Tg-equg-T10147-Ab-1/ GM-Tg-equg-T10147-Ab-2
Products NameAnti-R-PTP-sigma/PTPRS monoclonal antibody
Formatmab
Target NameR-PTP-sigma
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-R-PTP-sigma benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PTPRS/ R-PTP-sigma/ PTPSIGMA VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T10147
    Target NameR-PTP-sigma
    Gene ID5802,19280,25529,574274,485030,101083913,537480,102149682
    Gene Symbol and SynonymsLarptp2,PTP,PTP-NU3,PTPNU-3,Ptprd,PTPRS,PTPSIGMA,Ptpsigma.,Ptpt9,R-PTP-S,R-PTP-sigma,Rptpd,RPTPsigma
    Uniprot AccessionQ13332,Q64605
    Uniprot Entry NamePTPRS_HUMAN,PTPRS_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000105426
    Target ClassificationN/A

    The target: R-PTP-sigma, gene name: PTPRS, also named as PTPSIGMA, R-PTP-S, R-PTP-sigma. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.